Phorbol

SCHEMBL10590327

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nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Phorbol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	PRKCA	P17252	5/20	0.61

▸	PRKCG	P05129	5/20	0.61

▸	PRKD3	O94806	4/20	0.61

▸	PRKCB	P05771	4/20	0.61

▸	PRKCH	P24723	4/20	0.61

▸	PRKCI	P41743	4/20	0.61

▸	PRKCE	Q02156	4/20	0.61

▸	PRKCQ	Q04759	4/20	0.61

▸	PRKCZ	Q05513	4/20	0.61

▸	PRKCD	Q05655	4/20	0.61

▸	PRKD1	Q15139	4/20	0.61

▸	VAV1	P15498	2/20	0.57

▸	USP2	O75604	2/20	0.55

▸	TP53	P04637	2/20	0.55

▸	KDM4E	B2RXH2	1/20	0.55

▸	ALDH1A1	P00352	1/20	0.55

▸	SMN1; SMN2	Q16637	1/20	0.55

▸	CYP3A4	P08684	1/20	0.55

▸	CYP2C9	P11712	1/20	0.55

▸	TSHR	P16473	1/20	0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Phorbol SCHEMBL27470489	1.00	PRKCA (0.61)	PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL15976176	0.96	PRKCA (0.60)	PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL1733926	0.96	PRKCA (0.60)	PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL25166819	0.95	PRKCA (0.58)	PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL5310296	0.95	PRKCA (0.59)	PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL23880303	0.95	PRKCA (0.59)	PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL19435231	0.94	PRKCA (0.59)	PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27751207	0.93	PRKCA (0.56)	PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL7566989	0.92	PRKCA (0.60)	PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL11123948	0.92	PRKCA (0.61)	PRKCAPRKCGPRKD3PRKCBPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0334958-A1	MONOCLONAL ANTIBODIES	NIPPON SHINYAKU COMPANY, LIMITED (JP)	1989-10-04	—	—	EP	disclosed