Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phorbol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 5/20 | 0.60 |
| ▸ | PRKCG | P05129 | 5/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.60 |
| ▸ | PRKCB | P05771 | 4/20 | 0.60 |
| ▸ | PRKCH | P24723 | 4/20 | 0.60 |
| ▸ | PRKCI | P41743 | 4/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.60 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phorbol SCHEMBL27299282 | 0.93 | PRKCA (0.63) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL10590327 | 0.92 | PRKCA (0.61) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL27470489 | 0.92 | PRKCA (0.61) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL27419386 | 0.92 | PRKCA (0.62) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL7615331 | 0.92 | PRKCA (0.62) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL64353 | 0.92 | PRKCA (0.62) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL22973790 | 0.92 | PRKCA (0.62) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL27478115 | 0.89 | PRKCA (0.60) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL72895 | 0.89 | PRKCA (0.62) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL27572795 | 0.89 | PRKCA (0.62) | PRKCAPRKCGPRKD3PRKCBPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235934-A2 | SCREENING METHOD FOR CANDIDATE DRUGS | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038566-A2 | SCREENING METHOD FOR CANDIDATE DRUGS | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2001-05-31 | — | — | WO | disclosed |
| US-4753958-A | PSORIASIS | UNIVERSITY OF CAL (US) | 1988-06-28 | — | — | US | disclosed |