Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phorbol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 5/20 | 0.59 |
| ▸ | PRKCG | P05129 | 5/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.59 |
| ▸ | PRKCB | P05771 | 4/20 | 0.59 |
| ▸ | PRKCH | P24723 | 4/20 | 0.59 |
| ▸ | PRKCI | P41743 | 4/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.59 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.59 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.59 |
| ▸ | VAV1 | P15498 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phorbol SCHEMBL5667270 | 0.98 | PRKCA (0.60) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL3403135 | 0.98 | PRKCA (0.60) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL12950512 | 0.98 | PRKCA (0.60) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL1733926 | 0.98 | PRKCA (0.60) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL15976176 | 0.98 | PRKCA (0.60) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL2329457 | 0.98 | PRKCA (0.60) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL8190878 | 0.98 | PRKCA (0.60) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL14937 | 0.98 | PRKCA (0.60) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL23880303 | 0.97 | PRKCA (0.59) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL5310296 | 0.97 | PRKCA (0.59) | PRKCAPRKCGPRKD3PRKCBPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114085813-B | Method for evaluating substances having immunomodulatory properties | 集美大学 | 2024-02-27 | — | — | CN | claimed |
| CN-116874375-A | Phorbol ester derivatives and application thereof in anti-tumor aspect | 江苏省中国科学院植物研究所 | 2023-10-13 | — | — | CN | claimed |
| CN-111138263-B | Method for separating phorbol alcohol by utilizing ultrasonic-assisted alcoholysis-extraction coupling technology | 南昌大学 | 2021-07-20 | — | — | CN | claimed |
| CN-111269102-A | Method for extracting phorbol from croton oil by using Giralde reagent | 南昌大学 | 2020-06-12 | — | — | CN | claimed |
| CN-111138263-A | Method for separating phorbol alcohol by utilizing ultrasonic-assisted alcoholysis-extraction coupling technology | 南昌大学 | 2020-05-12 | — | — | CN | claimed |
| CN-114085813-B | Method for evaluating substances having immunomodulatory properties | 集美大学 | 2024-02-27 | — | — | CN | disclosed |
| CN-114085813-B | Method for evaluating substances having immunomodulatory properties | 集美大学 | 2024-02-27 | — | — | CN | disclosed |
| CN-116874375-A | Phorbol ester derivatives and application thereof in anti-tumor aspect | 江苏省中国科学院植物研究所 | 2023-10-13 | — | — | CN | disclosed |
| CN-116785282-A | A combined preparation for regulating intestinal microecology for preparing medicine for enhancing oncolytic virus immunotherapy effect | 济南微生态生物医学省实验室 | 2023-09-22 | — | — | CN | disclosed |
| CN-116785321-A | Application of microbial inoculum in preparation of preparation for enhancing oncolytic virus curative effect | 济南微生态生物医学省实验室 | 2023-09-22 | — | — | CN | disclosed |
| WO-2023123008-A1 | BIGUANIDE DERIVATIVE AND USE THEREOF | 北京大学深圳研究生院 | 2023-07-06 | — | — | WO | disclosed |
| CN-114457021-A | Pluripotent stem cell expressing CD47 antibody, derivative and application thereof | 未来智人再生医学研究院(广州)有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-111138263-B | Method for separating phorbol alcohol by utilizing ultrasonic-assisted alcoholysis-extraction coupling technology | 南昌大学 | 2021-07-20 | — | — | CN | disclosed |
| CN-113082071-A | Chinese patent medicine preparation for pneumonia and preparation method thereof | 南京康天生物科技有限公司 | 2021-07-09 | — | — | CN | disclosed |
| CN-112342196-A | Immune-compatible reversible universal pluripotent stem cell and application thereof | 未来智人再生医学研究院(广州)有限公司 | 2021-02-09 | — | — | CN | disclosed |
| CN-111269102-A | Method for extracting phorbol from croton oil by using Giralde reagent | 南昌大学 | 2020-06-12 | — | — | CN | disclosed |
| CN-111138263-A | Method for separating phorbol alcohol by utilizing ultrasonic-assisted alcoholysis-extraction coupling technology | 南昌大学 | 2020-05-12 | — | — | CN | disclosed |
| CN-111138263-A | Method for separating phorbol alcohol by utilizing ultrasonic-assisted alcoholysis-extraction coupling technology | 南昌大学 | 2020-05-12 | — | — | CN | disclosed |
| CN-106536500-B | Selective matrix metalloproteinase inhibitors | 圣母大学 | 2020-01-10 | — | — | CN | disclosed |
| US-20170292113-A1 | INFLAMMATION-TARGETED NEUTROPHIL GRANULOCYTE DRUG DELIVERY SYSTEM AND USE THEREOF | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2017-10-12 | — | — | US | disclosed |