SCHEMBL1059264

SCHEMBL1059264

O=C(O)C(F)(F)C(=O)CF

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ACLY P53396 2/20 0.32
ALDH1A1 P00352 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CASP1 P29466 1/20 0.32
THRB P10828 1/20 0.31
CES1 P23141 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15695436 0.77 CASP1 (0.32) CASP1
SCHEMBL7500204 0.74 CASP1 (0.30) CASP1
SCHEMBL5604100 0.74 FFAR3 (0.40) ACLYALDH1A1CES1
SCHEMBL7564418 0.74 FAAH (0.31) CASP1CES1
SCHEMBL8691775 0.74 TSHR (0.40) ACLYALDH1A1L3MBTL1CES1
SCHEMBL183177 0.74 CES2 (0.32) CASP1CES1
SCHEMBL4948143 0.73
SCHEMBL1360546 0.72 CASP1 (0.41) CASP1
SCHEMBL1360547 0.72 CASP1 (0.41) CASP1
SCHEMBL9143833 0.72 CES2 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3486241-B1 METHOD FOR PRODUCING CRYSTAL OF URACIL COMPOUND SUMITOMO CHEMICAL CO (JP) 2022-05-04 EP claimed
CN-114195714-A Simple synthesis method of celecoxib 山东铂源药业有限公司 2022-03-18 CN claimed
CN-106905153-B Method for preparing 2-chloro-4,4, 4-trifluoroacetylacetic acid ethyl ester by continuous non-catalytic reaction 浙江蓝天环保高科技股份有限公司 2020-08-18 CN claimed
EP-1812336-B1 PREPARATION METHOD OF MAGNETIC AND METAL OXIDE NANOPARTICLES UNIV YONSEI IACF (KR) 2015-11-11 EP claimed
EP-0938584-B1 METHOD OF PREPARING (S) - OR (R) -3,3,3-TRIFLUORO-2-HYDROXY-2- METHYLPROPIONIC ACID LONZA AG (CH) 2008-05-28 EP claimed
US-6893861-B1 Method for producing trifluoro-3(r)-hydroxybutyric acid derivatives LONZA AG (CH) 2005-05-17 US claimed
US-20040082043-A1 Enzymatic process for the preparation of optically active alcohols from ketones using tuberous root daucus carota COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2004-04-29 US claimed
EP-0767220-B1 Pyridonmethidazo dyes BAYER AG (DE) 1999-04-28 EP claimed
EP-0599036-B1 Method for the preparation of 2-aryl-5-trifluoromethyl pyrrole compounds AMERICAN CYANAMID CO (US) 1996-12-18 EP claimed
EP-0448544-B1 Process for preparation of fluoromethyl-substituted piperidine carbodithioates ROHM & HAAS (US) 1996-07-03 EP claimed
EP-0546669-B1 Preparation of fluorine-doped tungstic oxide and glass coating process FORD MOTOR CO (GB) 1996-04-17 EP claimed
EP-0599036-A1 Method for the preparation of 2-aryl-5-trifluoromethyl pyrrole compounds AMERICAN CYANAMID COMPANY (US) 1994-06-01 EP claimed
EP-0448544-A2 Process for preparation of fluoromethyl-substituted piperidine carbodithioates ROHM AND HAAS COMPANY (US) 1991-09-25 EP claimed
US-5039753-A Polymers comprising betadiketone groups and polymerizable compositions containing said polymers LOCTITE (IRELAND) LTD (IE) 1991-08-13 US claimed
EP-0270724-B1 PREPARATION OF ALKYL TRIFLUOROACETOACETATE Monsanto Company (US) 1990-11-28 EP claimed
EP-0313387-A2 Polymers comprising betadiketone groups and polymerizable compositions containing said polymers LOCTITE (IRELAND) Ltd. (IE) 1989-04-26 EP claimed
EP-0135491-B1 HERBICIDAL 2,6-BIS-FLUOROMETHYL-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID ESTERS MONSANTO COMPANY (US) 1989-01-25 EP claimed
EP-0158399-B1 LIQUID COATING COMPOSITION FOR PRODUCING HIGH QUALITY, HIGH PERFORMANCE FLUORINE-DOPED TIN OXIDE COATINGS M & T CHEMICALS, INC. (US) 1988-11-02 EP claimed
EP-0206953-B1 PROCESS FOR THE PREPARATION OF ETHYL TRIFLUOROACETOACETATE RHONE-POULENC CHIMIE (FR) 1988-09-07 EP claimed
EP-0206953-A1 Process for the preparation of ethyl trifluoroacetoacetate RHONE-POULENC CHIMIE (FR) 1986-12-30 EP claimed