Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 known ✓ | P35228 | 5/20 | 0.34 |
| ▸ | NOS1 known ✓ | P29475 | 4/20 | 0.34 |
| ▸ | NOS3 known ✓ | P29474 | 3/20 | 0.34 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.41 |
| ▸ | GABRE | P78334 | 2/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429137 | 0.84 | — | — | |
| Acetic Acid SCHEMBL9534162 | 0.79 | FFAR3 (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Acetic Acid SCHEMBL28331954 | 0.79 | GABRP (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Acetic Acid SCHEMBL3413269 | 0.79 | GABRP (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Acetic Acid SCHEMBL28454601 | 0.77 | FFAR3 (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Homoserine SCHEMBL28217776 | 0.75 | GSR (0.52) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| Acetic Acid SCHEMBL10585177 | 0.73 | GABRR1 (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Nitric Acid SCHEMBL10592572 | 0.73 | CA5A (0.38) | NOS1 | |
| Acetic Acid SCHEMBL2167990 | 0.73 | GABRR1 (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Acetic Acid SCHEMBL20387 | 0.73 | GABRR1 (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0098091-B1 | POLYMER COMPOSITIONS AND THEIR USE IN PRODUCING BINDERS, COATINGS AND ADHESIVES AND SUBSTRATES COATED OR IMPREGNATED THEREWITH | ROHM AND HAAS COMPANY (US) | 1989-04-19 | — | — | EP | disclosed |
| EP-0098091-A2 | Polymer compositions and their use in producing binders, coatings and adhesives and substrates coated or impregnated therewith | ROHM AND HAAS COMPANY (US) | 1984-01-11 | — | — | EP | disclosed |
| US-4420583-A | PROTECTIVE COATINGS, BINDERS, FILMS, ADHESIVES | ROHM AND HAAS COMPANY (US) | 1983-12-13 | — | — | US | disclosed |