Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.52 |
| ▸ | CASR | P41180 | 4/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10593198 | 0.87 | CASR (0.51) | CYP2D6CASRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10503937 | 0.83 | HTR1A (0.56) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10504063 | 0.83 | HTR1A (0.55) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10506852 | 0.83 | ADRB2 (0.52) | HTR1AHTR2BCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL10503983 | 0.83 | HTR1A (0.55) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10503738 | 0.81 | HTR1A (0.36) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10592316 | 0.80 | ABCB1 (0.43) | HTR1AADRA2ACASRSLC6A2SLC6A4 | |
| SCHEMBL8333897 | 0.80 | HTR1A (0.65) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| Fumaric Acid SCHEMBL10505860 | 0.80 | HTR1A (0.51) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10505596 | 0.79 | CYP2D6 (0.46) | HTR1AADRA2ACYP2D6CASRSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |