Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25119571 | 0.90 | MAPT (0.56) | MAPTADRB2ADRB1ADRB3MEN1 | |
| SCHEMBL16358433 | 0.84 | ADRB2 (0.59) | MAPTADRB2ADRB1ADRB3MEN1 | |
| SCHEMBL340618 | 0.83 | MAOB (0.67) | MAPTADRB2ADRB1ADRB3KMT2A | |
| SCHEMBL9663864 | 0.82 | CA1 (0.55) | MAPTMEN1KMT2ALMNANPSR1 | |
| SCHEMBL10599264 | 0.81 | HTT (0.50) | ADRB2ADRB1ADRB3L3MBTL1TSHR | |
| SCHEMBL11701711 | 0.80 | MAPT (0.64) | MAPTADRB2ADRB1ADRB3LMNA | |
| SCHEMBL8667480 | 0.80 | TDP1 (0.54) | MAPTKMT2ASMN1; SMN2L3MBTL1TSHR | |
| SCHEMBL11243132 | 0.80 | CA1 (0.60) | MAPTKMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL11243137 | 0.80 | CA1 (0.60) | MAPTKMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL300081 | 0.80 | CA1 (0.64) | ADRB2ADRB1ADRB3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175325-B1 | NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, THE PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pierrel S.p.A. (IT) | 1989-03-15 | — | — | EP | disclosed |
| US-4774325-A | ANTILIPEMIC AGENTS | PIERREL SPA (IT) | 1988-09-27 | — | — | US | disclosed |