Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21647724 | 0.86 | ABCB1 (0.44) | ADRB2ADRB1ADRB3TSHRABCB1 | |
| SCHEMBL340937 | 0.83 | HTT (0.69) | HTTL3MBTL1TSHRPPIA | |
| SCHEMBL28965964 | 0.81 | TSHR (0.52) | ADRB2ADRB1ADRB3L3MBTL1TSHR | |
| SCHEMBL10599258 | 0.81 | MAPT (0.62) | ADRB2ADRB1ADRB3L3MBTL1TSHR | |
| SCHEMBL14430331 | 0.80 | HTT (0.66) | HTTADRB2ADRB1ADRB3L3MBTL1 | |
| SCHEMBL11842718 | 0.79 | TSHR (0.49) | ADRB2ADRB1ADRB3TSHRABCB1 | |
| SCHEMBL14822991 | 0.79 | KDM4E (0.62) | ADRB2ADRB1ADRB3 | |
| SCHEMBL29191526 | 0.78 | PTGER1 (0.49) | — | |
| SCHEMBL28020536 | 0.77 | TSHR (0.61) | HTTADRB2ADRB1ADRB3TSHR | |
| SCHEMBL27898281 | 0.77 | L3MBTL1 (0.66) | HTTL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175325-B1 | NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, THE PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pierrel S.p.A. (IT) | 1989-03-15 | — | — | EP | disclosed |
| US-4774325-A | ANTILIPEMIC AGENTS | PIERREL SPA (IT) | 1988-09-27 | — | — | US | disclosed |