Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10627008 | 0.92 | ENPP1 (0.48) | APEX1PKMENPP1SMN1; SMN2LMNA | |
| SCHEMBL10599316 | 0.90 | PKM (0.46) | APEX1PKMENPP1SMN1; SMN2LMNA | |
| SCHEMBL10597447 | 0.89 | APEX1 (0.53) | APEX1PKMENPP1SMN1; SMN2LMNA | |
| SCHEMBL10598003 | 0.77 | LMNA (0.48) | APEX1PKMENPP1SMN1; SMN2LMNA | |
| SCHEMBL10601159 | 0.77 | GAA (0.47) | PKMENPP1LMNAALDH1A1NPSR1 | |
| SCHEMBL9692108 | 0.76 | ENPP1 (0.46) | APEX1PKMENPP1SMN1; SMN2LMNA | |
| SCHEMBL10599314 | 0.75 | MAPT (0.45) | PKMSMN1; SMN2LMNAALDH1A1HSD17B10 | |
| SCHEMBL9122697 | 0.73 | ENPP1 (0.48) | APEX1PKMENPP1SMN1; SMN2LMNA | |
| SCHEMBL9125618 | 0.71 | APEX1 (0.55) | APEX1PKMENPP1SMN1; SMN2LMNA | |
| SCHEMBL10598073 | 0.68 | HSPA5 (0.49) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175325-B1 | NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, THE PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pierrel S.p.A. (IT) | 1989-03-15 | — | — | EP | disclosed |
| US-4774325-A | ANTILIPEMIC AGENTS | PIERREL SPA (IT) | 1988-09-27 | — | — | US | disclosed |