Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9122697 | 0.90 | ENPP1 (0.48) | ENPP1APEX1ALDH1A1HSD17B10PKM | |
| SCHEMBL9125618 | 0.85 | APEX1 (0.55) | ENPP1APEX1ALDH1A1HSD17B10PKM | |
| SCHEMBL10599316 | 0.78 | PKM (0.46) | ENPP1APEX1ALDH1A1HSD17B10PKM | |
| SCHEMBL9692973 | 0.77 | EGFR (0.54) | ALDH1A1KMT2ALMNAHTT | |
| SCHEMBL10599653 | 0.76 | APEX1 (0.47) | ENPP1APEX1ALDH1A1HSD17B10PKM | |
| SCHEMBL10627008 | 0.75 | ENPP1 (0.48) | ENPP1APEX1ALDH1A1HSD17B10PKM | |
| SCHEMBL9125639 | 0.72 | PLA2G4B (0.41) | ENPP1APEX1ALDH1A1KDM4E | |
| SCHEMBL10597447 | 0.72 | APEX1 (0.53) | ENPP1APEX1ALDH1A1HSD17B10PKM | |
| SCHEMBL9124114 | 0.70 | RAB9A (0.50) | ALDH1A1KMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL10599314 | 0.70 | MAPT (0.45) | ALDH1A1HSD17B10PKMKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520552-A1 | Derivatives of (hetero) aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them | PIERREL S.p.A. (IT) | 1992-12-30 | — | — | EP | claimed |
| EP-0520552-A1 | Derivatives of (hetero) aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them | PIERREL S.p.A. (IT) | 1992-12-30 | — | — | EP | disclosed |