Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 6/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.62 |
| ▸ | ICMT | O60725 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253700 | 0.86 | OPRM1 (0.62) | OPRD1OPRM1ICMTKCNH2MEN1 | |
| SCHEMBL11310471 | 0.84 | OPRM1 (0.58) | OPRD1OPRM1ICMTMEN1KMT2A | |
| SCHEMBL2539292 | 0.81 | OPRD1 (0.65) | OPRD1OPRM1ABCB11KCNH2OPRK1 | |
| Hydrochloric Acid SCHEMBL2310717 | 0.79 | OPRD1 (0.63) | OPRD1OPRM1ABCB11KCNH2OPRK1 | |
| Bromide SCHEMBL7444095 | 0.79 | OPRD1 (0.63) | OPRD1OPRM1ABCB11KCNH2OPRK1 | |
| SCHEMBL8314711 | 0.78 | OPRD1 (0.58) | OPRD1OPRM1ABCB11KCNH2OPRK1 | |
| SCHEMBL4932269 | 0.77 | OPRD1 (1.00) | OPRD1OPRM1ABCB11KCNH2OPRK1 | |
| Hydrochloric Acid SCHEMBL10600734 | 0.76 | OPRD1 (0.57) | OPRD1OPRM1ABCB11KCNH2OPRK1 | |
| SCHEMBL7029726 | 0.76 | OPRD1 (0.48) | OPRD1OPRM1ABCB11KCNH2OPRK1 | |
| Hydrochloric Acid SCHEMBL7038471 | 0.75 | OPRD1 (0.47) | OPRD1OPRM1ABCB11KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0110435-B1 | NOVEL ((BIS(ARYL)METHYLENE)-1-PIPERIDINYL)ALKYL-PYRIMIDINONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-04 | — | — | EP | disclosed |
| US-4581171-A | ANTISEROTONINE AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1986-04-08 | — | — | US | disclosed |
| US-4533665-A | SEROTONIN ANTAGONIST | JANSSEN PHARMACEUTICA (BE) | 1985-08-06 | — | — | US | disclosed |
| US-4485107-A | SEDATIVES, MUSCLE RELAXANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-11-27 | — | — | US | disclosed |
| EP-0110435-A1 | Novel ((bis(aryl)methylene)-1-piperidinyl)alkyl-pyrimidinones | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-06-13 | — | — | EP | disclosed |