Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.63 |
| ▸ | PPARA | Q07869 | 13/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10603556 | 0.87 | PPARA (0.47) | PPARGPPARAMTNR1AALDH1A1HMGCR | |
| SCHEMBL4012223 | 0.79 | PPARG (0.55) | PPARGPPARAALDH1A1MEN1KMT2A | |
| SCHEMBL9720532 | 0.76 | ALDH1A1 (0.61) | PPARGPPARAALDH1A1HMGCRKDM4E | |
| SCHEMBL3407396 | 0.76 | MEN1 (0.65) | ALDH1A1HMGCRKDM4EMEN1KMT2A | |
| SCHEMBL3546860 | 0.75 | TPMT (0.58) | PPARGPPARAALDH1A1HMGCRKDM4E | |
| SCHEMBL25292370 | 0.74 | TPMT (0.56) | PPARGPPARAALDH1A1HMGCRKDM4E | |
| SCHEMBL6580876 | 0.74 | MAPT (0.44) | PPARGPPARAALDH1A1HMGCRKDM4E | |
| SCHEMBL26810030 | 0.74 | TPMT (0.51) | ALDH1A1KDM4EMEN1KMT2ABAZ2B | |
| SCHEMBL4013883 | 0.74 | PPARA (0.82) | PPARGPPARA | |
| SCHEMBL8473100 | 0.73 | HMGCR (0.44) | PPARGPPARAALDH1A1HMGCRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173279-B1 | 2-(3,5-DIALKYL-4-HYDROXYPHENYL)INDOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1989-08-23 | — | — | EP | disclosed |
| US-4695581-A | LIPOXYGENASE INHIBITOR | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1987-09-22 | — | — | US | disclosed |
| EP-0173279-A1 | 2-(3,5-Dialkyl-4-hydroxyphenyl)indole derivatives | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1986-03-05 | — | — | EP | disclosed |