Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.36 |
| ▸ | PRKACG | P22612 | 2/20 | 0.36 |
| ▸ | PRKACB | P22694 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | CHUK | O15111 | 3/20 | 0.35 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10607252 | 0.76 | APP (0.38) | PIM1PRKACAPRKACGPRKACBKDM4E | |
| SCHEMBL7056928 | 0.76 | KDM5B (0.39) | PIM1PIM3PIM2CYP11B1CYP11B2 | |
| SCHEMBL3440335 | 0.76 | GAA (0.51) | CYP11B2NPC1ALDH1A1RAB9A | |
| SCHEMBL5072719 | 0.74 | TDP1 (0.48) | CYP11B1CYP11B2PRKACAPRKACGPRKACB | |
| SCHEMBL8010306 | 0.73 | KEAP1 (0.41) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10724516 | 0.72 | CYP11B1 (0.31) | LRRK2CYP11B1CYP11B2 | |
| SCHEMBL10724509 | 0.72 | CYP11B1 (0.31) | LRRK2CYP11B1CYP11B2 | |
| SCHEMBL17983446 | 0.72 | ENPP3 (0.36) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8299041 | 0.72 | IDO1 (0.53) | LRRK2XDH | |
| SCHEMBL14191689 | 0.72 | TSHR (0.48) | CYP11B1CYP11B2PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0131973-B1 | NEW AMIDINE DERIVATIVES OF 2-SUBSTITUTED 4-PHENILIMIDAZOLE | ISTITUTO DE ANGELI S.p.A. (IT) | 1989-08-02 | — | — | EP | disclosed |
| US-4649150-A | ANTISECRETORY AGENTS | ISTITUTO DE ANGELI, S.P.A. (IT) | 1987-03-10 | — | — | US | disclosed |
| EP-0131973-A1 | New amidine derivatives of 2-substituted 4-phenilimidazole | ISTITUTO DE ANGELI S.p.A. (IT) | 1985-01-23 | — | — | EP | disclosed |