SCHEMBL10605992

SCHEMBL10605992

Nc1c(C2=NCCO2)cc([N+](=O)[O-])c2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.42
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
MAPK1 P28482 2/20 0.42
TP53 P04637 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
STAT6 P42226 1/20 0.42
HIF1A Q16665 1/20 0.42
PHLPP2 Q6ZVD8 1/20 0.42
HSD17B10 Q99714 1/20 0.42
MAPT P10636 4/20 0.41
POLB P06746 1/20 0.41
APEX1 P27695 1/20 0.41
CASP6 P55212 1/20 0.41
S100A4 P26447 2/20 0.38
PTPRC P08575 2/20 0.38
MAOB P27338 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10604381 0.93 ALDH1A1 (0.40) ALDH1A1CYP1A2CYP3A4MAPK1TP53
SCHEMBL4543383 0.77 ALDH1A1 (0.47) ALDH1A1MAPK1MAPTS100A4PTPRC
SCHEMBL11212007 0.75 MAPT (0.55) ALDH1A1CYP1A2CYP3A4MAPK1TP53
SCHEMBL11818043 0.74 MAPT (0.54) ALDH1A1CYP1A2CYP3A4MAPK1TP53
SCHEMBL8951807 0.72 CTSB (0.56) ALDH1A1CYP1A2CYP3A4MAPK1TP53
SCHEMBL13346218 0.72 MAPT (0.51) ALDH1A1CYP1A2CYP3A4MAPK1TP53
SCHEMBL10607788 0.72 CYP1A2 (0.59) ALDH1A1CYP1A2CYP3A4MAPK1TP53
SCHEMBL10611588 0.70 ADORA2A (0.46) ALDH1A1CYP1A2MAPTL3MBTL1P2RY2
SCHEMBL7967638 0.69 ALDH1A1 (0.45) ALDH1A1MAPK1MAPTS100A4PTPRC
Chlorobenzene SCHEMBL10892649 0.69 CYP1A1 (0.36) CYP1A2MAPK1MAPTPOLBP2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0111197-B1 ANTHRAQUINONE DYES, THEIR PREPARATION AND USE, AS WELL AS DICHROIC MATERIAL CONTAINING ANTHRAQUINONE DYES BAYER AG (DE) 1989-11-08 EP disclosed
US-4596666-A Aryl-mercapto anthraquinone dyestuffs, their preparation and use and dichroic material containing aryl-mercapto anthraquinone dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1986-06-24 US disclosed