Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 13/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.49 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10603555 | 0.92 | HIF1A (0.65) | HIF1ASMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL770501 | 0.89 | HIF1A (0.72) | HIF1ASMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL11046999 | 0.89 | HIF1A (0.53) | HIF1ASMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL7574132 | 0.89 | HIF1A (0.73) | HIF1ASMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL10883093 | 0.88 | HIF1A (0.63) | HIF1ASMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL871152 | 0.86 | HIF1A (0.76) | HIF1ASMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL10923487 | 0.86 | HIF1A (0.58) | HIF1ASMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL11110241 | 0.85 | HIF1A (0.62) | HIF1ASMN1; SMN2LMNAMAPTPOLB | |
| Hydrochloric Acid SCHEMBL11053488 | 0.85 | HIF1A (0.61) | HIF1ASMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL11108120 | 0.84 | HIF1A (0.61) | HIF1ASMN1; SMN2LMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4588718-A | ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1986-05-13 | — | — | US | claimed |
| EP-0157567-A2 | Carboxy-containing ester prodrugs of corticosteroids | THE UPJOHN COMPANY (US) | 1985-10-09 | — | — | EP | claimed |
| EP-0157567-B1 | CARBOXY-CONTAINING ESTER PRODRUGS OF CORTICOSTEROIDS | THE UPJOHN COMPANY (US) | 1989-11-29 | — | — | EP | disclosed |
| US-4588718-A | ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1986-05-13 | — | — | US | disclosed |