Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 5/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 13/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.73 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | PGR | P06401 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.55 |
| ▸ | AR | P10275 | 2/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL770501 | 0.92 | HIF1A (0.72) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL5712429 | 0.91 | HIF1A (0.74) | HIF1ALMNANFKB1PMP22TSHR | |
| Succinic Acid SCHEMBL1477515 | 0.90 | HIF1A (0.64) | HIF1ALMNANFKB1PMP22TSHR | |
| Succinic Acid SCHEMBL40948 | 0.90 | HIF1A (0.64) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL10527431 | 0.90 | HIF1A (0.62) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL10603555 | 0.88 | HIF1A (0.65) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL7574132 | 0.88 | HIF1A (0.73) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL7094755 | 0.88 | HIF1A (0.60) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL10700873 | 0.88 | HIF1A (0.64) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL13232 | 0.88 | HIF1A (0.74) | HIF1ALMNANFKB1PMP22TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 279 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1744683-B1 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE AGENTS | ALZA CORP (US) | 2016-03-16 | — | — | EP | claimed |
| US-8361022-B2 | Apparatus for transdermal delivery of parathyroid hormone agents | ALZA CORPORATION (US) | 2013-01-29 | — | — | US | claimed |
| US-20100152649-A1 | Apparatus and method for transdermal delivery of parathyroid hormone agents | ALZA CORPORATION (US) | 2010-06-17 | — | — | US | claimed |
| EP-1706176-A4 | FREQUENCY ASSISTED TRANSDERMAL AGENT DELIVERY METHOD AND SYSTEM | ALZA CORP (US) | 2008-06-25 | — | — | EP | claimed |
| EP-1686904-A4 | ULTRASOUND ASSISTED TRANSDERMAL VACCINE DELIVERY METHOD AND SYSTEM | ALZA CORP (US) | 2008-02-27 | — | — | EP | claimed |
| EP-1680178-A4 | SYSTEM AND METHOD FOR TRANSDERMAL VACCINE DELIVERY | ALZA CORP (US) | 2008-01-02 | — | — | EP | claimed |
| JP-2007530680-A | — | — | 2007-11-01 | — | — | JP | claimed |
| EP-1744683-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE AGENTS | ALZA Corporation (US) | 2007-01-24 | — | — | EP | claimed |
| EP-1737434-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF FENTANYL-BASED AGENTS | ALZA CORPORATION (US) | 2007-01-03 | — | — | EP | claimed |
| EP-1734993-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF INFLUENZA VACCINE | ALZA CORPORATION (US) | 2006-12-27 | — | — | EP | claimed |
| US-20050112135-A1 | Ultrasound assisted transdermal vaccine delivery method and system | ALZA CORPORATION | 2005-05-26 | — | — | US | claimed |
| WO-2005044366-A2 | SYSTEM AND METHOD FOR TRANSDERMAL VACCINE DELIVERY | ALZA CORPORATION (US) | 2005-05-19 | — | — | WO | claimed |
| WO-2005042702-A2 | COMPOSITIONS OF STABILIZED DNA FOR COATING MICROPROJECTIONS | ALZA CORPORATION (US) | 2005-05-12 | — | — | WO | claimed |
| US-20050090009-A1 | Compositions of stabilized DNA for coating microprojctions | ALZA CORPORATION | 2005-04-28 | — | — | US | claimed |
| US-20050049549-A1 | Method and device for enhancing transdermal agent flux | ALZA CORPORATION | 2005-03-03 | — | — | US | claimed |
| WO-2005016440-A1 | METHOD AND DEVICE FOR ENHANCING TRANSDERMAL AGENT FLUX | ALZA CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| US-20050031676-A1 | Method and device for enhancing transdermal agent flux | ALZA CORPORATION | 2005-02-10 | — | — | US | claimed |
| US-20050025778-A1 | Microprojection array immunization patch and method | ALZA CORPORATION | 2005-02-03 | — | — | US | claimed |
| WO-2005002453-A1 | MICROPROJECTION ARRAY IMMUNIZATION PATCH AND METHOD | ALZA CORPORATION (US) | 2005-01-13 | — | — | WO | claimed |
| WO-2003082251-A2 | THE EFFERVESCENT PHARMACEUTICAL DOSAGE FORM OF ESTERS AND ESTER SALTS OF 6 α METHYLPREDNISOLONE SUCCINATE, PROCEDURE FOR ITS OBTAINING AND APPLICATION | HEMOFARM KONCERN A.D. PHARMACEUTICAL AND CHEMICAL INDUSTRY (YU) | 2003-10-09 | — | — | WO | claimed |