Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10610746 | 0.91 | ALDH1A1 (0.44) | CCR5SRD5A2EPHX2SRD5A1POLB | |
| SCHEMBL3347314 | 0.86 | CCR5 (0.49) | CCR5SRD5A2EPHX2SRD5A1POLB | |
| SCHEMBL31370640 | 0.84 | ALDH1A1 (0.55) | CCR5SRD5A1POLBALDH1A1KMT2A | |
| SCHEMBL10606771 | 0.84 | EPHX2 (0.60) | SRD5A2EPHX2SRD5A1 | |
| SCHEMBL9595758 | 0.84 | EPHX2 (0.41) | CCR5EPHX2POLB | |
| SCHEMBL16308656 | 0.82 | POLB (0.56) | CCR5POLBALDH1A1KMT2AHTT | |
| SCHEMBL23410109 | 0.81 | CHRNA7 (0.46) | CCR5SRD5A2EPHX2SRD5A1POLB | |
| SCHEMBL21801725 | 0.81 | NAMPT (0.53) | CCR5SRD5A2EPHX2SRD5A1POLB | |
| SCHEMBL5545281 | 0.81 | EPHX2 (0.61) | EPHX2SRD5A1 | |
| SCHEMBL17279135 | 0.81 | ALK (0.55) | CCR5SRD5A2EPHX2SRD5A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147909-B1 | ARYLOXY-N-(AMINOALKYL)-1-PYRROLIDINE AND PIPERIDINE CARBOXAMIDES AND CARBOTHIOAMIDES HAVING ANTIARRHYTHMIC ACTIVITY | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-12-06 | — | — | EP | disclosed |
| US-4547514-A | Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-10-15 | — | — | US | disclosed |
| EP-0147909-A1 | Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-07-10 | — | — | EP | disclosed |