Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6379644 | 0.77 | ALDH1A1 (0.53) | ACHEGDAALDH1A1ADORA2AKDM4E | |
| SCHEMBL6904582 | 0.77 | ACHE (0.50) | ACHEGDAALDH1A1ADORA2BADORA2A | |
| SCHEMBL22487918 | 0.70 | KDM4E (0.39) | ALDH1A1KDM4ELMNAHSD17B10GLA | |
| SCHEMBL20830320 | 0.70 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNAHSD17B10GLA | |
| SCHEMBL1257032 | 0.67 | MAPKAPK2 (0.51) | ALDH1A1KDM4ESMN1; SMN2XDHRAB9A | |
| SCHEMBL31156527 | 0.67 | MAPKAPK2 (0.51) | ALDH1A1KDM4ESMN1; SMN2XDHRAB9A | |
| SCHEMBL6325739 | 0.67 | ACHE (0.39) | ACHEGDAADORA2BADORA2ALMNA | |
| SCHEMBL20830317 | 0.67 | ALDH1A1 (0.41) | ACHEGDAALDH1A1ADORA2AKDM4E | |
| SCHEMBL22487729 | 0.66 | L3MBTL1 (0.39) | ALDH1A1KDM4ELMNAHSD17B10GLA | |
| SCHEMBL28588392 | 0.64 | ALDH1A1 (0.65) | ACHEGDAALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670438-A | Imidazo[4,5-c]pyridazine-3-ones, imidazo[4,5-d]pyridazine-4-ones, imidazo[4,]pyrazin-5-ones, purin-2-ones, purin-6-ones, and purin-2,6-diones useful as hypotensive or cardiotonic agents | DR. KARL THOMAE GMBH (DE) | 1987-06-02 | — | — | US | claimed |
| EP-0130461-A2 | Imidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-01-09 | — | — | EP | claimed |
| US-4766130-A | 2-phenyl-imidazopyridin-ones and also useful as cardiotonics and anti-hypertensives | CELAMERCK GMBH & CO. KG (DE) | 1988-08-23 | — | — | US | disclosed |
| US-4670438-A | Imidazo[4,5-c]pyridazine-3-ones, imidazo[4,5-d]pyridazine-4-ones, imidazo[4,]pyrazin-5-ones, purin-2-ones, purin-6-ones, and purin-2,6-diones useful as hypotensive or cardiotonic agents | DR. KARL THOMAE GMBH (DE) | 1987-06-02 | — | — | US | disclosed |
| EP-0130461-A2 | Imidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-01-09 | — | — | EP | disclosed |