Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11245677 | 0.81 | NQO1 (0.45) | TP53SMN1; SMN2MAPTNPC1RAB9A | |
| Bromide SCHEMBL10456977 | 0.80 | KCNH2 (0.49) | SMN1; SMN2HTTKCNH2ACHE | |
| SCHEMBL14802086 | 0.77 | KCNH2 (0.50) | SMN1; SMN2MAPTHTTKCNH2ACHE | |
| SCHEMBL28493418 | 0.77 | ALDH1A1 (0.37) | SMN1; SMN2MAPTHTTALDH1A1 | |
| SCHEMBL5816509 | 0.76 | KCNH2 (0.53) | SMN1; SMN2MAPTHTTKCNH2ACHE | |
| SCHEMBL5814778 | 0.76 | KCNH2 (0.53) | SMN1; SMN2MAPTHTTKCNH2ACHE | |
| SCHEMBL5299903 | 0.76 | KCNH2 (0.53) | SMN1; SMN2MAPTHTTKCNH2ACHE | |
| SCHEMBL14740720 | 0.75 | CALM1 (0.44) | TP53SMN1; SMN2MAPTHTTKCNH2 | |
| SCHEMBL9095606 | 0.72 | TP53 (0.42) | TP53KCNH2ALDH1A1 | |
| Bromide SCHEMBL637005 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTHTTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260349-A1 | Dye diffusion transfer imaging process for production of retained images | AGFA-GEVAERT N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |