Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30425848 | 0.98 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTMAPTNPC1RAB9A | |
| SCHEMBL1263770 | 0.98 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTMAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL636847 | 0.98 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTMAPTNPC1RAB9A | |
| SCHEMBL7262939 | 0.80 | CA12 (0.37) | SMN1; SMN2HTTMAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL28754080 | 0.71 | MAPT (0.38) | SMN1; SMN2HTTMAPTTSHRBCL2 | |
| Hydrochloric Acid SCHEMBL6702513 | 0.71 | SMN1; SMN2 (0.39) | SMN1; SMN2HTTMAPTRAB9APOLB | |
| Hydrochloric Acid SCHEMBL10708206 | 0.71 | HDAC8 (0.40) | SMN1; SMN2HTTMAPTNPC1RAB9A | |
| Bromide SCHEMBL10613331 | 0.71 | TP53 (0.41) | SMN1; SMN2HTTMAPTNPC1RAB9A | |
| Bromide SCHEMBL11203324 | 0.71 | HDAC8 (0.40) | SMN1; SMN2HTTMAPTNPC1RAB9A | |
| SCHEMBL25530877 | 0.70 | CA12 (0.37) | SMN1; SMN2HTTMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006374-B1 | Process for producing a resin having a large refractive index | MITSUBISHI GAS CHEMICAL CO (JP) | 2009-01-07 | — | — | EP | claimed |
| WO-2024146848-A1 | CURABLE MATERIALS BASED ON CYCLIC THIOETHER COMPOUNDS, AND USES THEREOF | DELO INDUSTRIE KLEBSTOFFE GMBH & CO. KGAA (DE) | 2024-07-11 | — | — | WO | disclosed |
| EP-2735581-B1 | COMPOSITION AND POLYMER | ASAHI CHEMICAL IND (JP) | 2021-07-14 | — | — | EP | disclosed |
| EP-2799455-B1 | Resin composition for optical member and optical member obtained from the same | MITSUBISHI GAS CHEMICAL CO (JP) | 2018-03-28 | — | — | EP | disclosed |
| US-9738757-B2 | Composition and polymer | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2017-08-22 | — | — | US | disclosed |
| EP-2700636-B1 | PROCESS FOR PREPARING EPISULFIDE COMPOUNDS | ASAHI CHEMICAL IND (JP) | 2017-08-02 | — | — | EP | disclosed |
| US-9469731-B2 | Epoxide and thioepoxide functional, polymerizable composition and methods of preparing optical articles therefrom | PPG INDUSTRIES OHIO, INC. (US) | 2016-10-18 | — | — | US | disclosed |
| US-20160222168-A1 | Composition and Polymer | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2016-08-04 | — | — | US | disclosed |
| US-20160185910-A1 | Epoxide and Thioepoxide Functional, Polymerizable Composition and Methods of Preparing Optical Articles Therefrom | PPG INDUSTRIES OHIO, INC. | 2016-06-30 | — | — | US | disclosed |
| US-9359324-B2 | Process for preparing episulfide compounds | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2016-06-07 | — | — | US | disclosed |
| US-6534589-B1 | Catalytic curing and polymerization of episulfide compound in presence of phenolic compound | MITSUBISHI GAS CHEMICAL COMPANY INC. (JP) | 2003-03-18 | — | — | US | disclosed |
| US-6531532-B1 | Optical apparatus formed by curing sulfides, intermetallics and 1,2-bis/-epithiopropylthio/ethane to form lenses having large refractive index and optical distortion | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2003-03-11 | — | — | US | disclosed |
| US-6472495-B1 | RESIN PRODUCED BY CURING THE COMPOSITION BY POLYMERIZATION HAS AN EXCELLENT IMPACT RESISTANCE AND OPTICAL PROPERTIES, AND IS SUITABLE AS AN OPTICAL MATERIAL. POLYMERS WITH SULFIDE, SELINIUM AND TELLURIUM | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2002-10-29 | — | — | US | disclosed |
| EP-1099721-A1 | Composition for producing resin | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2001-05-16 | — | — | EP | disclosed |
| US-6201061-B1 | CURING A RESIN FOR OPTICAL USE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2001-03-13 | — | — | US | disclosed |
| EP-1046931-A2 | Composition for optical materials | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2000-10-25 | — | — | EP | disclosed |
| US-6130307-A | POLY(THIO)URETHANES | MITSUBISHI GAS CHEMICAL CO., INC. (JP) | 2000-10-10 | — | — | US | disclosed |
| EP-1006374-A2 | Process for producing a resin having a large refractive index | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2000-06-07 | — | — | EP | disclosed |
| EP-0950905-A2 | Process for producing a novel resin for optical materials having excellent color tone and transparency | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1999-10-20 | — | — | EP | disclosed |
| EP-0936233-A2 | Composition for a resin | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1999-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185910-A1 | Epoxide and Thioepoxide Functional, Polymerizable Composition and Methods of Preparing Optical Articles Therefrom | ALOX5, EPHX2, ALOX12 | ACHE 510/4885SMN1; SMN2 4074/4885HTT 3751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.