SCHEMBL10614568

SCHEMBL10614568

CCOC(=O)c1ccc(C#N)c(F)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.51
CA1 P00915 3/20 0.51
CA2 P00918 3/20 0.51
CA7 P43166 3/20 0.51
CA9 Q16790 3/20 0.51
CA14 Q9ULX7 3/20 0.51
ESR1 P03372 1/20 0.47
ESR2 Q92731 1/20 0.47
HSD17B2 P37059 1/20 0.47
LMNA P02545 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
MAOA P21397 1/20 0.46
TRPA1 O75762 1/20 0.45
HSD17B10 Q99714 3/20 0.45
ALDH1A1 P00352 3/20 0.45
KDM4E B2RXH2 3/20 0.45
MEN1 O00255 2/20 0.45
MAPT P10636 2/20 0.45
KMT2A Q03164 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29219333 0.90 KDM4E (0.43) CA12CA1CA2CA7CA9
SCHEMBL28289517 0.84 CA12 (0.54) CA12CA1CA2CA7CA9
SCHEMBL13193177 0.84 CA12 (0.54) CA12CA1CA2CA7CA9
SCHEMBL6990343 0.83 CA12 (0.53) CA12CA1CA2CA7CA9
SCHEMBL1275177 0.83 TRPA1 (0.51) CA12CA1CA2CA7CA9
SCHEMBL27487838 0.82 RAB9A (0.45) LMNAMAOAALDH1A1MEN1MAPT
SCHEMBL2421850 0.82 CA12 (0.51) CA12CA1CA2CA7CA9
SCHEMBL4180274 0.82 LMNA (0.54) CA12CA1CA2CA7CA9
SCHEMBL2474590 0.82 CA12 (0.51) CA12CA1CA2CA7CA9
SCHEMBL29900236 0.81 HSD17B2 (0.64) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117946303-A Catalyst, preparation method thereof, method for regulating and controlling ethylene polymerization kinetics behavior and application 中国石油化工股份有限公司 2024-04-30 CN claimed
CN-117946303-A Catalyst, preparation method thereof, method for regulating and controlling ethylene polymerization kinetics behavior and application 中国石油化工股份有限公司 2024-04-30 CN disclosed
CN-117946304-A Spherical catalyst component containing fluoroester electron donor, preparation method, catalyst and application thereof in ethylene polymerization 中国石油化工股份有限公司 2024-04-30 CN disclosed
US-4784471-A LIQUID CRYSTALS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1988-11-15 US disclosed
US-4704227-A DERIVATIVES OF 1,3-DIOXANE MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1987-11-03 US disclosed