SCHEMBL10614570

SCHEMBL10614570

N#COc1ccccc1C=Cc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 7/20 0.59
TRPA1 O75762 3/20 0.59
CYP1A1 P04798 4/20 0.44
CYP1A2 P05177 4/20 0.44
CYP1B1 Q16678 4/20 0.44
MAOB P27338 1/20 0.41
CYP19A1 P11511 1/20 0.41
ALOX5 P09917 1/20 0.38
PTGS1 P23219 1/20 0.38
PTGS2 P35354 1/20 0.38
TUBB4A P04350 1/20 0.37
TUBB P07437 1/20 0.37
TUBA3C P0DPH7 1/20 0.37
TUBA1B P68363 1/20 0.37
TUBA4A P68366 1/20 0.37
TUBB4B P68371 1/20 0.37
TUBB3 Q13509 1/20 0.37
TUBB2A Q13885 1/20 0.37
TUBB8 Q3ZCM7 1/20 0.37
TUBA3E Q6PEY2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10614563 1.00 NFE2L2 (0.59) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
Hydrogen Sulfide SCHEMBL28231457 0.98 NFE2L2 (0.58) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
Water SCHEMBL28632016 0.80 NFE2L2 (0.68) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL29032542 0.79 NFE2L2 (0.39) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL1654495 0.78 NFE2L2 (0.70) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL1654497 0.78 NFE2L2 (0.70) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL6536304 0.77 HTT (0.61) NFE2L2
SCHEMBL9218104 0.75 KDM4E (0.42) NFE2L2TRPA1
SCHEMBL9250953 0.75 CYP11B1 (0.40) NFE2L2TRPA1
SCHEMBL23744199 0.75 ALDH1A1 (0.40) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4762900-A FROM EPOXIDE AND ISOCYANATE NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1988-08-09 US disclosed