Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.60 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10614242 | 0.87 | ADORA2B (0.53) | — | |
| SCHEMBL10617168 | 0.85 | ADORA2B (0.49) | — | |
| SCHEMBL10614807 | 0.85 | ADORA2B (0.57) | — | |
| SCHEMBL10616203 | 0.84 | ADORA2B (0.51) | — | |
| SCHEMBL4650748 | 0.81 | ADORA2B (0.74) | — | |
| SCHEMBL10614388 | 0.80 | ADORA2B (0.60) | — | |
| SCHEMBL10614219 | 0.75 | ADORA2B (0.52) | — | |
| SCHEMBL10617164 | 0.73 | KDM4E (0.62) | — | |
| SCHEMBL897036 | 0.71 | PDE1A (1.00) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL25090647 | 0.71 | KDM4E (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769377-A | Adenosine receptor antagonists | THE JOHNS HOPKINS UNIVERSITY (US) | 1988-09-06 | — | — | US | disclosed |