Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | XPO1 | O14980 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23714118 | 0.82 | KMT2A (0.55) | PIM1PIM2TP53KMT2ALMNA | |
| SCHEMBL23714067 | 0.81 | NCF1 (0.53) | PIM1PIM2TP53ARPDE3B | |
| SCHEMBL22135112 | 0.78 | KMT2A (0.68) | PIM1TP53KMT2ALMNATSHR | |
| SCHEMBL22545406 | 0.76 | CACNA1C (0.42) | KMT2AKDM4EL3MBTL1ARPDE3B | |
| SCHEMBL1702521 | 0.76 | KARS1 (0.50) | TP53KMT2ALMNATSHRRAB9A | |
| SCHEMBL1702629 | 0.76 | KMT2A (0.47) | PIM1PIM2TP53KMT2ALMNA | |
| SCHEMBL23714119 | 0.74 | KDM4E (0.50) | TP53KMT2ALMNARAB9AKDM4E | |
| SCHEMBL23714120 | 0.73 | ELANE (0.50) | TP53LMNATSHRKDM4EHTT | |
| SCHEMBL38650982 | 0.73 | PIM1 (0.40) | PIM1PIM2LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL1702468 | 0.72 | DHFR (0.58) | KMT2ARAB9AKDM4ENPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1988001621-A1 | 4-AMINOQUINOLINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-03-10 | — | — | WO | disclosed |
| EP-0259174-A1 | Derivatives of 4-aminoquinoline and their use as medicaments | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-03-09 | — | — | EP | disclosed |