Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HEXA | P06865 | 1/20 | 0.31 |
| ▸ | HEXB | P07686 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10901005 | 0.74 | HSP90AB1 (0.48) | HRH4MAPTHSP90AB1TSHRHSP90AA1 | |
| SCHEMBL763785 | 0.73 | HRH4 (0.37) | HRH4KMT2AMAPTHSP90AB1MEN1 | |
| SCHEMBL10618268 | 0.71 | SMN1; SMN2 (0.40) | HRH4KMT2AHSP90AB1ADORA2AADORA1 | |
| SCHEMBL6829600 | 0.71 | HSP90AB1 (0.49) | MAPTHSP90AB1TSHRHSP90AA1 | |
| SCHEMBL191457 | 0.69 | KMT2A (0.59) | KMT2AMAPTHSP90AB1MEN1HSP90AA1 | |
| SCHEMBL10619523 | 0.69 | HSP90AB1 (0.56) | HRH4KMT2AMAPTHSP90AB1MEN1 | |
| SCHEMBL10617499 | 0.69 | ALDH1A1 (0.46) | HRH4HSP90AB1ADORA2AHSP90AA1 | |
| SCHEMBL763729 | 0.67 | TLR8 (0.42) | HRH4KMT2AHSP90AB1MEN1 | |
| SCHEMBL10618233 | 0.67 | NPC1 (0.51) | HRH4 | |
| SCHEMBL27828127 | 0.67 | ALDH1A1 (0.47) | HSP90AB1HEXAHEXBADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4723006-A | CHEMICAL INTERMEDIATES | CIBA-GEIGY CORPORATION (US) | 1988-02-02 | — | — | US | disclosed |
| EP-0111440-A1 | 2-Aminopyrimidines, their production and use | CIBA-GEIGY AG (CH) | 1984-06-20 | — | — | EP | disclosed |