SCHEMBL10026577

SCHEMBL10026577

Cc1ccc(-c2coc3cc(O)cc(O)c3c2=O)cc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.81
MEN1 O00255 6/20 0.81
KMT2A Q03164 6/20 0.81
SMN1; SMN2 Q16637 6/20 0.81
ALDH1A1 P00352 6/20 0.81
RAB9A P51151 6/20 0.81
TP53 P04637 5/20 0.81
HPGD P15428 5/20 0.81
NPC1 O15118 5/20 0.81
ALOX15 P16050 4/20 0.81
CYP3A4 P08684 3/20 0.81
HSD17B2 P37059 3/20 0.81
CYP2C9 P11712 3/20 0.81
CYP2C19 P33261 3/20 0.81
MAPK1 P28482 3/20 0.81
POLB P06746 3/20 0.81
TSHR P16473 3/20 0.81
EGFR P00533 3/20 0.81
ABCB1 P08183 3/20 0.81
AKR1B10 O60218 2/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13640743 0.90 MEN1 (0.65) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
Genistein SCHEMBL29352944 0.90 MAPT (1.00) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
Genistein SCHEMBL19166 0.90 MAPT (1.00) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
Genistein SCHEMBL554056 0.90 MAPT (1.00) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
Genistein SCHEMBL551801 0.88 MAPT (0.97) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
Genistein SCHEMBL38650814 0.88 MAPT (0.97) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
Genistein SCHEMBL31168045 0.88 MAPT (0.97) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
Genistein SCHEMBL551352 0.88 MAPT (0.97) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
Genistein SCHEMBL551402 0.88 MAPT (0.97) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
Genistein SCHEMBL551449 0.88 MAPT (0.97) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES THE BROAD INSTITUTE, INC. 2024-01-25 US disclosed
US-20230200388-A1 COMPOUNDS AND METHODS FOR STIMULATING PLANTS Sound Agriculture Company (US) 2023-06-29 US disclosed
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF THE BROAD INSTITUTE, INC. 2023-06-22 US disclosed
US-20180185303-A1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2018-07-05 US disclosed
US-9974766-B2 Prenylated isoflavones for treatment of subjects with multidrug-resistant cancer MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY (MO) 2018-05-22 US disclosed
US-9783592-B2 Glucagon superfamily peptides exhibiting nuclear hormone receptor activity INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2017-10-10 US disclosed
WO-2017090007-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF UREA CYCLE DISORDERS AND HEPATIC DISEASES RAO M SURYA (IN) 2017-06-01 WO disclosed
US-20170151212-A1 PRENYLATED ISOFLAVONES FOR TREATMENT OF SUBJECTS WITH MULTIDRUG-RESISTANT CANCER MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2017-06-01 US disclosed
US-20170049793-A1 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY THE GENERAL HOSPITAL CORPORATION (US) 2017-02-23 US disclosed
US-20160367693-A1 Selective Arylation of Dichalcogenides in Biomolecules NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-12-22 US disclosed
US-9127088-B2 Glucagon superfamily peptides exhibiting nuclear hormone receptor activity INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-09-08 US disclosed
US-20150152187-A1 Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides AMBRX, INC. (US) 2015-06-04 US disclosed
US-20140187510-A1 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY THE GENERAL HOSPITAL CORPORATION (US) 2014-07-03 US disclosed
US-20140073611-A1 METHODS FOR DRUG SCREEN USING ZEBRAFISH MODEL AND THE COMPOUNDS SCREENED THEREFROM NATIONAL TAIWAN UNIVERSITY (TW) 2014-03-13 US disclosed
US-20130123178-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING NUCLEAR HORMONE RECEPTOR ACTIVITY INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2013-05-16 US disclosed
US-20120283313-A1 INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS NORTHWESTERN UNIVERSITY (US) 2012-11-08 US disclosed
US-20120046242-A1 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2012-02-23 US disclosed
US-20110262482-A1 ANTI-VIRAL COMPOUNDS Kineta, Inc. (US) 2011-10-27 US disclosed
US-20070037875-A1 Genistein inhibition of transthyretin amyloidosis THE SCRIPPS RESEARCH INSTITUTE (US) 2007-02-15 US disclosed
US-4117149-A 4-OXO-4H-BENZOPYRANS AS ANIMAL GROWTH PROMOTANTS PFIZER INC. (US) 1978-09-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120046242-A1 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY WNT1, CTNNB1, WNT3A MAPT 2364/4885MEN1 4099/4885KMT2A 3873/4885
US-20110262482-A1 ANTI-VIRAL COMPOUNDS MAVS, EIF2AK2, IRF3 MAPT 3520/4885MEN1 4873/4885KMT2A 3571/4885
US-20150152187-A1 Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides AR, PSMA1, NR2E3 MAPT 1286/4885MEN1 689/4885KMT2A 1416/4885
US-20170151212-A1 PRENYLATED ISOFLAVONES FOR TREATMENT OF SUBJECTS WITH MULTIDRUG-RESISTANT CANCER ABCB1, ABCC1, ABCB11 MAPT 4795/4885MEN1 2461/4885KMT2A 3183/4885
US-20160367693-A1 Selective Arylation of Dichalcogenides in Biomolecules SCLY, SELENOI, TPO MAPT 4521/4885MEN1 1132/4885KMT2A 3830/4885
US-20180185303-A1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER MAOA, COMT, MAOB MAPT 592/4885MEN1 2198/4885KMT2A 444/4885
US-20070037875-A1 Genistein inhibition of transthyretin amyloidosis TTR, SHBG, TTPA MAPT 90/4885MEN1 1444/4885KMT2A 4252/4885
US-20120283313-A1 INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS MAPK4, MAP4K4, MAP3K4 MAPT 2493/4885MEN1 302/4885KMT2A 772/4885
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES COASY, JMJD7, PTMS MAPT 3572/4885MEN1 3675/4885KMT2A 2272/4885
US-20130123178-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING NUCLEAR HORMONE RECEPTOR ACTIVITY GIPR, GLP1R, GCGR MAPT 4294/4885MEN1 3189/4885KMT2A 3131/4885
US-20140073611-A1 METHODS FOR DRUG SCREEN USING ZEBRAFISH MODEL AND THE COMPOUNDS SCREENED THEREFROM PLOD3, MYOC, SLTM MAPT 2354/4885MEN1 4287/4885KMT2A 3355/4885
US-20140187510-A1 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY WNT1, CTNNB1, WNT3A MAPT 2364/4885MEN1 4099/4885KMT2A 3873/4885
US-20230200388-A1 COMPOUNDS AND METHODS FOR STIMULATING PLANTS SNRK, GRK1, PPIP5K2 MAPT 4278/4885MEN1 3498/4885KMT2A 3582/4885
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF ERBB2, ACP1, TK1 MAPT 3770/4885MEN1 3627/4885KMT2A 1636/4885
US-20170049793-A1 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY WNT1, CTNNB1, WNT3A MAPT 2364/4885MEN1 4099/4885KMT2A 3873/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.