Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10618516 | 0.85 | HSD17B10 (0.53) | MEP1BKDM4ETDP1MAPTTUBB1 | |
| SCHEMBL1461671 | 0.85 | KDM4E (0.49) | KDM4ETDP1MAPTPDE4DMEN1 | |
| SCHEMBL10680843 | 0.81 | KDM4E (0.40) | KDM4ETDP1MAPTPDE4DMEN1 | |
| SCHEMBL17462499 | 0.79 | SMN1; SMN2 (0.45) | MAPTMEN1KMT2ASMN1; SMN2CA1 | |
| SCHEMBL31287934 | 0.79 | MEP1B (0.43) | MEP1BPDE4D | |
| SCHEMBL11289422 | 0.78 | ALDH1A1 (0.45) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6353960 | 0.78 | AOC3 (0.41) | MEP1BKDM4EMAPTSMN1; SMN2LMNA | |
| SCHEMBL7274336 | 0.78 | PDE4A (0.42) | MEP1BKDM4ETDP1MAPTTUBB1 | |
| SCHEMBL3658261 | 0.77 | HSD17B10 (0.50) | KDM4EMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL2532788 | 0.77 | KMT2A (0.49) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209275-B1 | BENZ-TRISUBSTITUTED 2-AMINOTETRALINS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-10-19 | — | — | EP | disclosed |
| EP-0209275-A1 | Benz-trisubstituted 2-aminotetralins | SMITHKLINE BECKMAN CORPORATION (US) | 1987-01-21 | — | — | EP | disclosed |