Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.70 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.70 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | P2RY1 | P47900 | 6/20 | 0.65 |
| ▸ | P2RX4 | Q99571 | 6/20 | 0.65 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.65 |
| ▸ | SRC | P12931 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.62 |
| ▸ | MACROD2 | A1Z1Q3 | 1/20 | 0.61 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.61 |
| ▸ | MACROD1 | Q9BQ69 | 1/20 | 0.61 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.61 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19147171 | 1.00 | P2RX3 (0.70) | P2RX3P2RX1P2RX2POLBP2RY1 | |
| SCHEMBL12932290 | 1.00 | P2RX3 (0.70) | P2RX3P2RX1P2RX2POLBP2RY1 | |
| SCHEMBL30134678 | 1.00 | P2RX3 (0.70) | P2RX3P2RX1P2RX2POLBP2RY1 | |
| SCHEMBL703733 | 0.91 | POLB (0.80) | P2RX3P2RX1P2RX2POLBP2RY1 | |
| SCHEMBL5044161 | 0.91 | POLB (0.80) | P2RX3P2RX1P2RX2POLBP2RY1 | |
| SCHEMBL14471000 | 0.91 | POLB (0.80) | P2RX3P2RX1P2RX2POLBP2RY1 | |
| SCHEMBL29350133 | 0.91 | POLB (0.80) | P2RX3P2RX1P2RX2POLBP2RY1 | |
| SCHEMBL78250 | 0.91 | POLB (0.80) | P2RX3P2RX1P2RX2POLBP2RY1 | |
| SCHEMBL18785117 | 0.91 | POLB (0.80) | P2RX3P2RX1P2RX2POLBP2RY1 | |
| SCHEMBL889289 | 0.91 | POLB (0.80) | P2RX3P2RX1P2RX2POLBP2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451980-B1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | TRILINK BIOTECHNOLOGIES (US) | 2014-05-21 | — | — | EP | claimed |
| US-8728725-B2 | Chemically modified ligase cofactors, donors and acceptors | TRILINK BIOTECHNOLOGIES (US) | 2014-05-20 | — | — | US | claimed |
| US-20110008788-A1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | TriLink Bio Technologies | 2011-01-13 | — | — | US | claimed |
| US-12428658-B2 | Methods and compositions for enzymatic polymerization of N3′→P5′ phosphoramidate DNA | THE GENERAL HOSPITAL CORPORATION (US) | 2025-09-30 | — | — | US | disclosed |
| US-20240309418-A1 | ENZYMATIC METHODS AND COMPOSITIONS FOR POLYMERIZATION OF PHOSPHORAMIDATE AND THIOPHOSPHORAMIDATE-LINKED DNA | MASSACHUSETTS GEN HOSPITAL (US) | 2024-09-19 | — | — | US | disclosed |
| WO-2024192269-A2 | ENZYMATIC METHODS AND COMPOSITIONS FOR POLYMERIZATION OF PHOSPHORAMIDATE AND THIOPHOSPHORAMIDATE-LINKED DNA | THE GENERAL HOSPITAL CORPORATION (US) | 2024-09-19 | — | — | WO | disclosed |
| US-20230026693-A1 | Methods and Compositions for Enzymatic Polymerization of N3` -> P5` Phosphoramidate DNA | THE GENERAL HOSPITAL CORPORATION | 2023-01-26 | — | — | US | disclosed |
| WO-2021108632-A1 | METHODS AND COMPOSITIONS FOR ENZYMATIC POLYMERIZATION OF N3' -> P5' PHOSPHORAMIDATE DNA | THE GENERAL HOSPITAL CORPORATION (US) | 2021-06-03 | — | — | WO | disclosed |
| US-20170275672-A1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | TRILINK BIOTECHNOLOGIES, INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-9631227-B2 | Chemically modified ligase cofactors, donors and acceptors | TRILINK BIOTECHNOLOGIES, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| EP-2971133-A1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | Trilink Biotechnologies, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20140323354-A1 | Chemically Modified Ligase Cofactors, Donors and Acceptors | TRILINK BIOTECHNOLOGIES, INC. (US) | 2014-10-30 | — | — | US | disclosed |
| WO-2014144979-A1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | TRILINK BIOTECHNOLOGIES, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| EP-2451980-B1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | TRILINK BIOTECHNOLOGIES (US) | 2014-05-21 | — | — | EP | disclosed |
| US-8728725-B2 | Chemically modified ligase cofactors, donors and acceptors | TRILINK BIOTECHNOLOGIES (US) | 2014-05-20 | — | — | US | disclosed |
| EP-2451980-A1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | TriLink BioTechnologies (US) | 2012-05-16 | — | — | EP | disclosed |
| US-20110008788-A1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | TriLink Bio Technologies | 2011-01-13 | — | — | US | disclosed |