Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10622394 | 0.78 | SMN1; SMN2 (0.58) | CHRNB2CHRNA4MAPK1GAAMAPT | |
| SCHEMBL10625325 | 0.73 | CYP3A4 (0.46) | CHRNB2CHRNA4MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL10626570 | 0.70 | KMT2A (0.49) | GAAKDM4EKMT2ACRHBPCRHR2 | |
| SCHEMBL7898965 | 0.70 | MEN1 (0.46) | CHRNB2CHRNA4TRPM5MAPK1GAA | |
| SCHEMBL21261501 | 0.69 | CYP19A1 (0.46) | CHRNB2CHRNA4MAPK1GAAMAPT | |
| Hydrochloric Acid SCHEMBL10626522 | 0.68 | CYP11B2 (0.35) | CHRNB2CHRNA4CHRNA7CYP19A1CYP11B1 | |
| SCHEMBL156842 | 0.67 | CHRNB2 (0.56) | CHRNB2CHRNA4MAPK1MAPTKDM4E | |
| SCHEMBL4991736 | 0.67 | CYP2A6 (0.45) | CHRNB2CHRNA4MAPK1GAAKDM4E | |
| SCHEMBL10622377 | 0.66 | KMT2A (0.40) | GAAKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL10624676 | 0.66 | KMT2A (0.45) | CHRNB2CHRNA4GAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183369-A2 | Dihydroisoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-06-04 | — | — | EP | claimed |
| US-4745115-A | ANTIALLERGENS, RHEUMATIC DISEASES | BEECHAM GROUP P.L.C. (GB) | 1988-05-17 | — | — | US | disclosed |
| EP-0183369-A2 | Dihydroisoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-06-04 | — | — | EP | disclosed |