Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901769 | 0.82 | MEN1 (0.46) | MEN1KMT2AMAPK1KDM4EMAPT | |
| SCHEMBL7900671 | 0.75 | CHRNB2 (0.50) | MEN1KMT2AMAPK1KDM4EMAPT | |
| SCHEMBL7899655 | 0.73 | CHRNB2 (0.42) | MEN1KMT2AMAPK1KDM4EMAPT | |
| SCHEMBL7896803 | 0.73 | CYP2C9 (0.40) | MEN1KMT2AMAPK1KDM4EMAPT | |
| SCHEMBL156842 | 0.71 | CHRNB2 (0.56) | MEN1KMT2AMAPK1KDM4EMAPT | |
| SCHEMBL10623972 | 0.70 | CHRNB2 (0.38) | MEN1KMT2AMAPK1KDM4EMAPT | |
| SCHEMBL9469201 | 0.69 | MAPT (0.43) | MEN1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL7898968 | 0.69 | CHRNB2 (0.46) | MEN1KMT2AMAPK1KDM4EMAPT | |
| SCHEMBL30542609 | 0.68 | PBRM1 (0.41) | MEN1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL7903182 | 0.68 | CHRNB2 (0.45) | MEN1KMT2AMAPK1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |