Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.61 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10330766 | 0.91 | ALDH1A1 (0.63) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL3136282 | 0.90 | TOP2A (0.66) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9149649 | 0.88 | TOP2A (0.67) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL3984286 | 0.87 | TOP2A (0.62) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL2184237 | 0.87 | TOP2A (0.62) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL25669903 | 0.87 | ALDH1A1 (0.64) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL29962586 | 0.85 | ALDH1A1 (0.66) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL500386 | 0.85 | ALDH1A1 (0.66) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10330765 | 0.85 | TOP2A (0.69) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10925284 | 0.85 | KCNH2 (0.46) | TOP2ATOP2BALDH1A1POLBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4762844-A | ANIMAL GROWTH REGULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1988-08-09 | — | — | US | claimed |
| EP-0181588-A2 | Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, process for their preparation, and antibacterial agents containing them | BAYER AG (DE) | 1986-05-21 | — | — | EP | claimed |
| US-8252783-B2 | Quinolone carboxylic acids, derivatives thereof, and methods of making and using same | BAUSCH & LOMB INCORPORATED (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100029936-A1 | Quinolone Carboxylic Acids, Derivatives Thereof, and Methods of Making and Using Same | BAUSCH+LOMB OPS B.V. (NL) | 2010-02-04 | — | — | US | disclosed |
| US-7632944-B2 | Quinolone carboxylic acids, derivatives thereof, and methods of making and using same | BAUSCH & LOMB INCORPORATED (US) | 2009-12-15 | — | — | US | disclosed |
| US-20080176834-A1 | Quinolone Carboxylic Acids, Derivatives Thereof, and Methods of Making and Using Same | PRECISION DERMATOLOGY, INC. | 2008-07-24 | — | — | US | disclosed |
| US-4762844-A | ANIMAL GROWTH REGULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1988-08-09 | — | — | US | disclosed |
| EP-0181588-A2 | Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, process for their preparation, and antibacterial agents containing them | BAYER AG (DE) | 1986-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029936-A1 | Quinolone Carboxylic Acids, Derivatives Thereof, and Methods of Making and Using Same | NQO2, QARS1, QPCT | TOP2A 175/4885TOP2B 202/4885ALDH1A1 363/4885 |
| US-20080176834-A1 | Quinolone Carboxylic Acids, Derivatives Thereof, and Methods of Making and Using Same | NQO2, QARS1, QPCT | TOP2A 212/4885TOP2B 279/4885ALDH1A1 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.