Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10626619 | 0.88 | OPRK1 (0.52) | OPRK1OPRD1 | |
| SCHEMBL10629968 | 0.88 | OPRK1 (0.52) | OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL10626614 | 0.87 | OPRK1 (0.52) | OPRK1OPRD1 | |
| SCHEMBL10626756 | 0.86 | OPRD1 (0.36) | OPRK1OPRD1HDAC8 | |
| SCHEMBL10947532 | 0.85 | SIGMAR1 (0.45) | OPRK1OPRD1OPRM1 | |
| SCHEMBL10630095 | 0.85 | OPRK1 (0.53) | OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL10976444 | 0.84 | SIGMAR1 (0.44) | OPRK1OPRD1HDAC8OPRM1 | |
| SCHEMBL10421906 | 0.82 | OPRK1 (0.44) | OPRK1OPRD1 | |
| SCHEMBL10771138 | 0.82 | OPRK1 (0.44) | OPRK1OPRD1 | |
| SCHEMBL10632814 | 0.82 | OPRK1 (0.44) | OPRK1OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154234-A2 | Substituted tyrosil alanine dipeptide amides | G.D. Searle & Co. (US) | 1985-09-11 | — | — | EP | claimed |
| US-4727189-A | ANALGESICS, ANTIHYPERTENSIVE AGENTS | G. D. SEARLE & CO. (US) | 1988-02-23 | — | — | US | disclosed |
| US-4599325-A | ANALGESIC, HYPOTENSIVE | G. D. SEARLE & CO. (US) | 1986-07-08 | — | — | US | disclosed |