Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.62 |
| ▸ | PDE2A | O00408 | 2/20 | 0.62 |
| ▸ | PDE1A | P54750 | 1/20 | 0.62 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.62 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 2/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10552154 | 0.86 | PDE3A (0.48) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10688158 | 0.85 | PDE3A (0.47) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10353457 | 0.77 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Tetrahydrobenximidazole SCHEMBL10625034 | 0.76 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7280920 | 0.76 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10620570 | 0.76 | PDE3B (0.63) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11268997 | 0.76 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7296342 | 0.76 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16157002 | 0.76 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16157200 | 0.75 | PDE3B (0.73) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4717730-A | HYPOTENSIVE AND CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1988-01-05 | — | — | US | disclosed |