Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 6/20 | 1.00 |
| ▸ | PDE2A | O00408 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10962496 | 0.78 | PDE2A (0.64) | PDE3BPDE3APDE2ASMN1; SMN2HTT | |
| SCHEMBL10629606 | 0.76 | PDE3B (0.62) | PDE3BPDE3APDE2ASMN1; SMN2PDE4A | |
| SCHEMBL2531256 | 0.76 | HTT (0.78) | PDE3BPDE3APDE2ASMN1; SMN2CYP1A2 | |
| SCHEMBL2643248 | 0.76 | PDE2A (0.61) | PDE3BPDE3APDE2ASMN1; SMN2PDE4A | |
| SCHEMBL7289586 | 0.75 | PDE3B (1.00) | PDE3BPDE3APDE2ASMN1; SMN2LMNA | |
| SCHEMBL3419279 | 0.74 | HTT (0.88) | SMN1; SMN2HTTFGFR1KDM4EALDH1A1 | |
| SCHEMBL30402227 | 0.74 | HTT (0.88) | SMN1; SMN2HTTFGFR1KDM4EALDH1A1 | |
| SCHEMBL10353452 | 0.74 | SMN1; SMN2 (0.81) | PDE3BPDE3APDE2ASMN1; SMN2LMNA | |
| SCHEMBL7303341 | 0.74 | PDE3B (0.72) | PDE3BPDE3APDE2ASMN1; SMN2LMNA | |
| SCHEMBL7280158 | 0.73 | PDE3B (0.58) | PDE3BPDE3APDE2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | claimed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | claimed |
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |