Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9159414 | 0.79 | ALDH1A1 (0.57) | CYP11B1CYP11B2IDO1ALDH1A1L3MBTL1 | |
| SCHEMBL31114399 | 0.77 | CCR1 (0.56) | CYP11B1CYP11B2IDO1ALDH1A1L3MBTL1 | |
| SCHEMBL31114208 | 0.77 | CYP11B1 (0.47) | CYP11B1CYP11B2IDO1ALDH1A1L3MBTL1 | |
| SCHEMBL21661952 | 0.77 | KDM1A (0.51) | IDO1ALDH1A1HSD17B10ALOX5APFEN1 | |
| SCHEMBL15006447 | 0.77 | CCR1 (0.56) | CYP11B1CYP11B2IDO1ALDH1A1L3MBTL1 | |
| SCHEMBL4390590 | 0.73 | CCR1 (0.46) | ALDH1A1L3MBTL1HSD17B10KDM4ENPC1 | |
| SCHEMBL6283314 | 0.73 | — | — | |
| SCHEMBL13771808 | 0.73 | CYP11B1 (0.57) | CYP11B1CYP11B2IDO1ALDH1A1L3MBTL1 | |
| SCHEMBL13765803 | 0.73 | S1PR1 (0.48) | CYP11B1CYP11B2IDO1ALDH1A1L3MBTL1 | |
| SCHEMBL6018826 | 0.73 | CYP11B1 (0.47) | CYP11B1CYP11B2IDO1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268143-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | Forest Laboratories Holdings Limited (BM) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117676-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | WO | disclosed |