Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.70 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | ADH5 | P11766 | 5/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290528 | 0.83 | PDE3B (1.00) | PDE3BPDE3AADH5ROCK1PDE2A | |
| SCHEMBL10553489 | 0.79 | PDE3B (0.69) | PDE3BPDE3APIM1ADH5CLK4 | |
| SCHEMBL10353678 | 0.72 | PDE3B (0.63) | PDE3BPDE3ACLK4METPDGFRB | |
| SCHEMBL10645524 | 0.72 | PDE3B (0.61) | PDE3BPDE3APIM1ADH5EGLN2 | |
| SCHEMBL7276956 | 0.70 | PDE3B (0.59) | PDE3BPDE3APIM1ADH5PDE2A | |
| SCHEMBL10649130 | 0.70 | PDE3B (0.65) | PDE3BPDE3AADH5PDE2A | |
| SCHEMBL10631471 | 0.69 | KMT2A (0.40) | PDE3BPDE3APIM1ADH5EGLN2 | |
| SCHEMBL10551860 | 0.68 | PDE3B (0.46) | PDE3BPDE3APIM1ADH5GAA | |
| SCHEMBL8815628 | 0.68 | GAA (0.50) | PIM1EGLN2GAACLK4CYP1A2 | |
| SCHEMBL10468163 | 0.68 | PDE3A (0.70) | PDE3BPDE3APIM1GAACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847251-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |
| EP-0255704-A2 | Pyridazinone derivatives, process for their preparation and their use as medicines | Roche Diagnostics GmbH (DE) | 1988-02-10 | — | — | EP | disclosed |