Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.58 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 5/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10630616 | 1.00 | KLK5 (0.58) | KLK5TRPM8SYKATMREN | |
| SCHEMBL10350971 | 0.91 | KLK5 (0.57) | KLK5TRPM8SYKATMCTRB1 | |
| SCHEMBL10634825 | 0.89 | REN (0.54) | KLK5SYKRENCTSK | |
| SCHEMBL10630534 | 0.89 | REN (0.54) | KLK5SYKRENCTSK | |
| SCHEMBL10628675 | 0.89 | SYK (0.55) | KLK5TRPM8SYKATMREN | |
| SCHEMBL10628809 | 0.89 | SYK (0.55) | KLK5TRPM8SYKATMREN | |
| SCHEMBL6931617 | 0.86 | KLK5 (0.59) | KLK5TRPM8SYKATMCTRB1 | |
| SCHEMBL27805989 | 0.86 | SYK (0.52) | KLK5TRPM8SYKATMREN | |
| SCHEMBL27805991 | 0.86 | SYK (0.52) | KLK5TRPM8SYKATMREN | |
| SCHEMBL9833378 | 0.83 | KLK5 (0.72) | KLK5RENPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755592-A | Statine-containing peptides useful in medicaments | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-07-05 | — | — | US | disclosed |
| US-4746649-A | Diamino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1988-05-24 | — | — | US | disclosed |