Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of 2-Phenylphenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | HPGD | P15428 | 1/20 | 0.77 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | BACE1 | P56817 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Phenylphenol SCHEMBL27831345 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| SCHEMBL28366972 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL29360750 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL14249267 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL29811 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL27504029 | 0.86 | ALDH1A1 (0.85) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL2415939 | 0.86 | ALDH1A1 (0.85) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL8617992 | 0.86 | HPGD (0.85) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL7622365 | 0.85 | ALDH1A1 (0.94) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL8152306 | 0.85 | ALDH1A1 (0.94) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107955080-A | It is a kind of that there is the anti-oxidant and method of the white shellfish acidic polysaccharose of liver protection effect from Bai Beizhong extractions | 淮阴工学院 | 2018-04-24 | — | — | CN | disclosed |
| CN-103869002-A | Analysis method for determining oligomerization thelenota ananas glycosaminoglycan content | SHENZHEN NEPTUNUS PHARMACEUTIC | 2014-06-18 | — | — | CN | disclosed |
| US-4746673-A | PHYTOPATHOGENS | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1988-05-24 | — | — | US | disclosed |