Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 7/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10642519 | 0.95 | HTR7 (0.57) | ADRA2ADRD2ADRA2BDRD3HTR7 | |
| SCHEMBL10637728 | 0.95 | HTR7 (0.57) | ADRA2ADRD2ADRA2BDRD3HTR7 | |
| SCHEMBL11037653 | 0.90 | ADRA2A (0.68) | ADRA2ADRD2ADRA2BDRD3HTR7 | |
| SCHEMBL11019133 | 0.85 | HTR7 (0.61) | ADRA2ADRD2ADRA2BDRD3HTR7 | |
| SCHEMBL10637608 | 0.85 | ADRA2A (0.70) | ADRA2ADRD2ADRA2BDRD3HTR7 | |
| SCHEMBL10642057 | 0.85 | ADRA2A (0.72) | ADRA2ADRD2ADRA2BDRD3HTR7 | |
| SCHEMBL10640698 | 0.85 | ADRA2A (0.55) | ADRA2ADRD2ADRA2BDRD3HTR7 | |
| SCHEMBL10644101 | 0.83 | ADRA2A (0.49) | ADRA2ADRD2ADRA2BDRD3HTR7 | |
| SCHEMBL10639460 | 0.83 | ADRA2A (0.72) | ADRA2ADRD2ADRA2BDRD3HTR7 | |
| Hydrochloric Acid SCHEMBL10643416 | 0.83 | ADRA2A (0.49) | ADRA2ADRD2ADRA2BDRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161498-B1 | PHENYLPIPERAZINE DERIVATIVES AND THEIR ACID ADDITION SALTS | MITSUBISHI KASEI CORPORATION (JP) | 1988-10-12 | — | — | EP | disclosed |
| US-4716161-A | HYPOTENSIVE AGENTS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1987-12-29 | — | — | US | disclosed |
| EP-0161498-A1 | Phenylpiperazine derivatives and their acid addition salts | MITSUBISHI KASEI CORPORATION (JP) | 1985-11-21 | — | — | EP | disclosed |