Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841406 | 0.75 | MEN1 (0.36) | MEN1LMNAKMT2ACHRNB2CHRNA4 | |
| Bromide SCHEMBL9522713 | 0.74 | MEN1 (0.36) | MEN1LMNAKMT2ACHRNB2CHRNA4 | |
| SCHEMBL19490544 | 0.72 | ADRA2A (0.36) | MEN1LMNAKMT2ACHRNB2CHRNA4 | |
| SCHEMBL15482996 | 0.70 | MEN1 (0.38) | MEN1LMNAKMT2ACHRNB2CHRNA4 | |
| SCHEMBL9610894 | 0.69 | LMNA (0.40) | MEN1LMNAKMT2AP2RX7CYP1A2 | |
| SCHEMBL2067075 | 0.69 | SLC6A4 (0.39) | MEN1LMNAKMT2ACYP1A2CYP2C19 | |
| SCHEMBL2067077 | 0.69 | SLC6A4 (0.39) | MEN1LMNAKMT2ACYP1A2CYP2C19 | |
| SCHEMBL12283943 | 0.68 | CYP2D6 (0.33) | MEN1LMNAKMT2ACYP2D6SLC6A2 | |
| SCHEMBL12199391 | 0.68 | CYP2D6 (0.33) | MEN1LMNAKMT2ACYP2D6SLC6A2 | |
| SCHEMBL12199222 | 0.68 | CYP2D6 (0.33) | MEN1LMNAKMT2ACYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120770-B1 | 2-AMINOETHYL PYRIDINE OR PYRAZINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RIOM LABORATOIRES- C.E.R.M. "R.L.-CERM" - (S.A.) (FR) | 1988-03-23 | — | — | EP | disclosed |
| US-4668679-A | BRONCHODILATOR AGENTS | RIOM LABORATORIES C.E.R.M. (FR) | 1987-05-26 | — | — | US | disclosed |
| EP-0120770-A1 | 2-Aminoethyl pyridine or pyrazine derivatives, their preparation and pharmaceutical compositions containing them | RIOM LABORATOIRES- C.E.R.M. "R.L.-CERM" - (S.A.) (FR) | 1984-10-03 | — | — | EP | disclosed |