Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19490544 | 0.79 | ADRA2A (0.36) | MEN1LMNAKMT2AADRA2AADRA2B | |
| SCHEMBL15482996 | 0.77 | MEN1 (0.38) | MEN1LMNAKMT2AADRA2AADRA2B | |
| SCHEMBL9156006 | 0.77 | NNMT (0.43) | MEN1KMT2ACYP2A6HRH1 | |
| SCHEMBL6881691 | 0.77 | — | — | |
| SCHEMBL1321806 | 0.77 | CYP26A1 (0.33) | CHRNB2CHRNA4 | |
| SCHEMBL2644227 | 0.77 | NOS3 (0.45) | HDAC1HDAC6PDE10A | |
| SCHEMBL12199391 | 0.75 | CYP2D6 (0.33) | MEN1LMNAKMT2AADRA2AADRA2B | |
| SCHEMBL10639265 | 0.75 | MEN1 (0.35) | MEN1LMNAKMT2ACYP2D6SLC6A2 | |
| SCHEMBL12199222 | 0.75 | CYP2D6 (0.33) | MEN1LMNAKMT2AADRA2AADRA2B | |
| SCHEMBL12283943 | 0.75 | CYP2D6 (0.33) | MEN1LMNAKMT2AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579733-B1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | UPJOHN CO (US) | 2001-06-20 | — | — | EP | disclosed |
| US-5441971-A | Antidiabetic agents | THE UPJOHN COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0579733-A1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | PHARMACIA & UPJOHN COMPANY (US) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992018501-A1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |