Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | LMNA | P02545 | 8/20 | 0.47 |
| ▸ | HTT | P42858 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MITF | O75030 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13545967 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL10639290 | 0.73 | LMNA (0.40) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL5726136 | 0.72 | LMNA (0.40) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL4311290 | 0.72 | TSHR (0.43) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL6593278 | 0.71 | LMNA (0.38) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL10639775 | 0.69 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL5726004 | 0.67 | GSK3B (0.42) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL2978000 | 0.67 | COMT (0.49) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| Hydrochloric Acid SCHEMBL10731665 | 0.65 | MAPT (0.47) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL18358038 | 0.64 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172031-B1 | NOVEL SULFENYLATED ACYLHYDRAZONES, COMPOSITIONS CONTAINING THEM, METHODS OF MAKING THEM AND THEIR USE | ROHM AND HAAS COMPANY (US) | 1988-05-18 | — | — | EP | disclosed |
| EP-0172031-A1 | Novel sulfenylated acylhydrazones, compositions containing them, methods of making them and their use | ROHM AND HAAS COMPANY (US) | 1986-02-19 | — | — | EP | disclosed |