Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP9 | P55211 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1483376 | 0.76 | ALDH1A1 (0.55) | SMN1; SMN2LMNAHTTMAPTALDH1A1 | |
| SCHEMBL9557865 | 0.76 | ATM (0.48) | SMN1; SMN2LMNAHTTMAPTGAA | |
| SCHEMBL1937600 | 0.73 | LMNA (0.54) | SMN1; SMN2LMNAHTTMAPTALDH1A1 | |
| SCHEMBL9559030 | 0.71 | ATM (0.54) | SMN1; SMN2LMNAHTTMAPTGAA | |
| SCHEMBL14364100 | 0.70 | HTT (0.54) | SMN1; SMN2LMNAHTTMAPTGAA | |
| SCHEMBL11608228 | 0.69 | CYP1A2 (0.77) | SMN1; SMN2LMNAHTTMAPTGAA | |
| SCHEMBL10639764 | 0.69 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAHTTMAPTGAA | |
| SCHEMBL3268354 | 0.69 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAHTTMAPTKDM4E | |
| SCHEMBL218867 | 0.68 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAHTTMAPTALDH1A1 | |
| SCHEMBL23529356 | 0.67 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAHTTMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172031-B1 | NOVEL SULFENYLATED ACYLHYDRAZONES, COMPOSITIONS CONTAINING THEM, METHODS OF MAKING THEM AND THEIR USE | ROHM AND HAAS COMPANY (US) | 1988-05-18 | — | — | EP | disclosed |
| EP-0172031-A1 | Novel sulfenylated acylhydrazones, compositions containing them, methods of making them and their use | ROHM AND HAAS COMPANY (US) | 1986-02-19 | — | — | EP | disclosed |