Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 3/20 | 0.66 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | XIAP | P98170 | 1/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | PLG | P00747 | 1/20 | 0.54 |
| ▸ | C1S | P09871 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288202 | 1.00 | TPH1 (0.66) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL1397441 | 1.00 | TPH1 (0.66) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL288201 | 1.00 | TPH1 (0.66) | TPH1SLC7A5PTGS1ALPIPKM | |
| Hydrochloric Acid SCHEMBL5279289 | 0.98 | TPH1 (0.64) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL20714851 | 0.86 | PRSS1 (0.50) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL668746 | 0.85 | TPH1 (0.70) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL21690013 | 0.85 | TPH1 (0.70) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL668747 | 0.85 | TPH1 (0.70) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL7272904 | 0.85 | TPH1 (0.50) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL2310526 | 0.84 | SLC7A5 (0.83) | TPH1SLC7A5PTGS1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486892-B2 | Blood coagulation factor inhibitors | NOVO NORDISK HEALTH CARE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-20110229453-A1 | BLOOD COAGULATION FACTOR INHIBITORS | NOVO NORDISK HEALTH CARE AG (CH) | 2011-09-22 | — | — | US | disclosed |
| US-20110003752-A1 | New Blood Coagulation Factor Inhibitors | NOVO NORDISK HEALTH CARE A/G (CH) | 2011-01-06 | — | — | US | disclosed |
| EP-2235042-A1 | NEW BLOOD COAGULATION FACTOR INHIBITORS | Novo Nordisk Health Care AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| EP-2190860-A1 | BLOOD COAGULATION FACTOR INHIBITORS | Novo Nordisk Health Care AG (CH) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009092758-A1 | NEW BLOOD COAGULATION FACTOR INHIBITORS | NOVO NORDISK HEALTH CARE AG (DK) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009024571-A1 | BLOOD COAGULATION FACTOR INHIBITORS | NOVO NORDISK HEALTH CARE AG (DK) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003752-A1 | New Blood Coagulation Factor Inhibitors | F7, F12, F5 | TPH1 4428/4885SLC7A5 1684/4885PTGS1 3013/4885 |
| US-20110229453-A1 | BLOOD COAGULATION FACTOR INHIBITORS | F5, TFPI, F7 | TPH1 4114/4885SLC7A5 2649/4885PTGS1 973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.