Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 3/20 | 0.66 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | XIAP | P98170 | 1/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | PLG | P00747 | 1/20 | 0.54 |
| ▸ | C1S | P09871 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288202 | 1.00 | TPH1 (0.66) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL1397441 | 1.00 | TPH1 (0.66) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL1064252 | 1.00 | TPH1 (0.66) | TPH1SLC7A5PTGS1ALPIPKM | |
| Hydrochloric Acid SCHEMBL5279289 | 0.98 | TPH1 (0.64) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL20714851 | 0.86 | PRSS1 (0.50) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL668746 | 0.85 | TPH1 (0.70) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL21690013 | 0.85 | TPH1 (0.70) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL668747 | 0.85 | TPH1 (0.70) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL7272904 | 0.85 | TPH1 (0.50) | TPH1SLC7A5PTGS1ALPIPKM | |
| SCHEMBL2310526 | 0.84 | SLC7A5 (0.83) | TPH1SLC7A5PTGS1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695191-B2 | Conformationally constrained, fully synthetic macrocyclic compounds | POLYPHOR AG (CH) | 2017-07-04 | — | — | US | claimed |
| EP-2462147-B1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2014-11-12 | — | — | EP | claimed |
| US-20120202821-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2012-08-09 | — | — | US | claimed |
| US-20110312873-A1 | N-TERMINALLY MODIFIED TETRAPEPTIDE DERIVATIVES HAVING A C-TERMINAL ARGININE MIMETIC | PHILIPPS-UNIVERSITAT MARBURG (DE) | 2011-12-22 | — | — | US | claimed |
| EP-2349312-A2 | N-TERMINALLY MODIFIED TETRAPEPTIDE DERIVATIVES HAVING A C-TERMINAL ARGININE MIMETIC | Philipps-Universität Marburg (DE) | 2011-08-03 | — | — | EP | claimed |
| WO-2010048941-A2 | N-TERMINALLY MODIFIED TETRAPEPTIDE DERIVATIVES HAVING A C-TERMINAL ARGININE MIMETIC | PHILIPPS-UNIVERSITÄT MARBURG (DE) | 2010-05-06 | — | — | WO | claimed |
| US-20050119190-A1 | Inhibitors of the blood-clotting factor xa, production thereof and use of the same | CURACYTE AG (DE) | 2005-06-02 | — | — | US | claimed |
| EP-1483285-A1 | INHIBITORS OF THE BLOOD-CLOTTING FACTOR Xa, PRODUCTION THEREOF AND USE OF THE SAME | Curacyte AG (DE) | 2004-12-08 | — | — | EP | claimed |
| WO-2003076457-A1 | INHIBITORS OF THE BLOOD-CLOTTING FACTOR Xa, PRODUCTION THEREOF AND USE OF THE SAME | CURACYTE AG (DE) | 2003-09-18 | — | — | WO | claimed |
| EP-3087094-B1 | BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS | POLYPHOR AG (CH) | 2022-06-01 | — | — | EP | disclosed |
| US-10273267-B2 | Beta-hairpin peptidomimetics as selective elastase inhibitors | POLYPHOR AG (CH) | 2019-04-30 | — | — | US | disclosed |
| US-20170369523-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS THAT ARE LIGANDS FOR G-PROTEIN-COUPLED RECEPTORS (GPCRS) AND ARE MODULATORS OF TRANSCRIPTION FACTORS AND COACTIVATORS | POLYPHOR AG (CH) | 2017-12-28 | — | — | US | disclosed |
| WO-2017141032-A1 | TREATMENT OF FIBROTIC DISORDERS | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2017-08-24 | — | — | WO | disclosed |
| US-9695191-B2 | Conformationally constrained, fully synthetic macrocyclic compounds | POLYPHOR AG (CH) | 2017-07-04 | — | — | US | disclosed |
| EP-1355674-B1 | OLIGO ALKYLENE GLYCOL OR POLYALKYLENE GLYCOL-COUPLED THROMBIN INHIBITORS | JENAFFIN GMBH (DE) | 2010-10-27 | — | — | EP | disclosed |
| US-20050119190-A1 | Inhibitors of the blood-clotting factor xa, production thereof and use of the same | CURACYTE AG (DE) | 2005-06-02 | — | — | US | disclosed |
| EP-1355674-A2 | OLIGO OR POLYALKYLENE GLYCOL-COUPLED THROMBIN INHIBITORS | HaemoSys GmbH (DE) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002059065-A2 | OLIGO OR POLYALKYLENE GLYCOL-COUPLED THROMBIN INHIBITORS | HAEMOSYS GMBH (DE) | 2002-08-01 | — | — | WO | disclosed |
| US-5627283-A | ANTITHROMBIN COMPOUNDS | BEHRINGWERKE AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | disclosed |
| US-5457114-A | Antithrombin; antithrombotic, enzyme resistance, tolerability | BEHRINGWERKE AKTIENGESELLSCHAFT (DE) | 1995-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202821-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | HTR2B, MC1R, HTR1A | TPH1 76/4885SLC7A5 1600/4885PTGS1 109/4885 |
| US-20050119190-A1 | Inhibitors of the blood-clotting factor xa, production thereof and use of the same | SERPINC1, TFPI, F11 | TPH1 4262/4885SLC7A5 4712/4885PTGS1 1407/4885 |
| US-10273267-B2 | Beta-hairpin peptidomimetics as selective elastase inhibitors | SERPINB1, ELANE, XPNPEP1 | TPH1 3030/4885SLC7A5 1527/4885PTGS1 2416/4885 |
| US-20170369523-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS THAT ARE LIGANDS FOR G-PROTEIN-COUPLED RECEPTORS (GPCRS) AND ARE MODULATORS OF TRANSCRIPTION FACTORS AND COACTIVATORS | NCOA1, NCOA2, NCOR1 | TPH1 3130/4885SLC7A5 4428/4885PTGS1 1682/4885 |
| US-20110312873-A1 | N-TERMINALLY MODIFIED TETRAPEPTIDE DERIVATIVES HAVING A C-TERMINAL ARGININE MIMETIC | FURIN, IAPP, APP | TPH1 3561/4885SLC7A5 2233/4885PTGS1 3773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.