Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL125255 | 0.82 | ALDH1A1 (0.57) | SLC6A4SLC6A2ALDH1A1TSHRSLC6A3 | |
| SCHEMBL29729780 | 0.82 | ALDH1A1 (0.57) | SLC6A4SLC6A2ALDH1A1TSHRSLC6A3 | |
| SCHEMBL3812562 | 0.76 | PYCR1 (0.69) | ALDH1A1TSHRLMNACYP3A4SMN1; SMN2 | |
| SCHEMBL20657966 | 0.73 | SLC6A4 (0.48) | SLC6A4SLC6A2ALDH1A1TSHRSLC6A3 | |
| Alcohol SCHEMBL28875867 | 0.73 | SLC6A4 (0.53) | SLC6A4SLC6A2ALDH1A1TSHRSLC6A3 | |
| SCHEMBL329228 | 0.73 | SLC6A4 (0.48) | SLC6A4SLC6A2ALDH1A1TSHRSLC6A3 | |
| SCHEMBL12188870 | 0.73 | SLC6A4 (0.48) | SLC6A4SLC6A2ALDH1A1TSHRSLC6A3 | |
| SCHEMBL8310680 | 0.73 | CYP2C19 (0.46) | SLC6A4SLC6A2ALDH1A1TSHRSLC6A3 | |
| SCHEMBL22275491 | 0.73 | SLC6A4 (0.46) | SLC6A4SLC6A2ALDH1A1TSHRSLC6A3 | |
| SCHEMBL4302816 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159376-B1 | 1-(AMINOALKYLPHENYL AND AMINOALKYLBENZYL)-INDOLES AND INDOLINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-11-02 | — | — | EP | disclosed |