Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648144 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2TP53NPSR1GPR84MEN1 | |
| SCHEMBL10646513 | 0.85 | SMN1; SMN2 (0.67) | SMN1; SMN2TP53NPSR1GPR84MEN1 | |
| SCHEMBL8534922 | 0.85 | SMN1; SMN2 (1.00) | SMN1; SMN2TP53NPSR1GPR84MEN1 | |
| SCHEMBL9340089 | 0.84 | SMN1; SMN2 (0.66) | SMN1; SMN2TP53NPSR1GPR84MEN1 | |
| Ethoxycarbonyl Group SCHEMBL27597866 | 0.82 | SMN1; SMN2 (0.77) | SMN1; SMN2TP53NPSR1GPR84MEN1 | |
| SCHEMBL10645611 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2TP53NPSR1GPR84MEN1 | |
| SCHEMBL10646985 | 0.81 | SMN1; SMN2 (0.73) | SMN1; SMN2TP53NPSR1GPR84MEN1 | |
| SCHEMBL9441061 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2TP53NPSR1GPR84MEN1 | |
| SCHEMBL2980233 | 0.80 | SMN1; SMN2 (0.71) | SMN1; SMN2TP53NPSR1GPR84MEN1 | |
| SCHEMBL3279652 | 0.79 | GPR84 (0.79) | SMN1; SMN2TP53NPSR1GPR84MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0149419-B1 | ACYLINDOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1988-08-17 | — | — | EP | claimed |
| US-4708961-A | ANTICOAGULANTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1987-11-24 | — | — | US | claimed |
| EP-0149419-A1 | Acylindole derivatives and pharmaceutical compositions containing them | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1985-07-24 | — | — | EP | claimed |
| EP-0149419-B1 | ACYLINDOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1988-08-17 | — | — | EP | disclosed |
| US-4708961-A | ANTICOAGULANTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1987-11-24 | — | — | US | disclosed |
| EP-0149419-A1 | Acylindole derivatives and pharmaceutical compositions containing them | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1985-07-24 | — | — | EP | disclosed |