Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118340 | 0.98 | KEAP1 (0.59) | HPGDPTGS2RECQLKEAP1KMT2A | |
| SCHEMBL2044935 | 0.92 | KIF11 (0.59) | HPGDPTGS2RECQLKEAP1KMT2A | |
| SCHEMBL3555520 | 0.88 | KDM4E (0.59) | HPGDPTGS2RECQLKEAP1KMT2A | |
| SCHEMBL10417625 | 0.86 | HPGD (0.56) | HPGDPTGS2RECQLKEAP1KMT2A | |
| SCHEMBL3019804 | 0.85 | PTPN11 (0.50) | HPGDPTGS2RECQLKEAP1KMT2A | |
| SCHEMBL13157249 | 0.85 | NPC1 (0.59) | HPGDPTGS2RECQLKEAP1KMT2A | |
| SCHEMBL3555970 | 0.84 | NPC1 (0.61) | HPGDRECQLLMNASMN1; SMN2PGR | |
| SCHEMBL4624606 | 0.82 | HPGD (0.64) | HPGDPTGS2RECQLKEAP1KMT2A | |
| SCHEMBL7745099 | 0.82 | HPGD (0.59) | HPGDPTGS2RECQLKEAP1CA12 | |
| SCHEMBL27183018 | 0.82 | PTPRB (0.57) | KMT2ACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0158775-B1 | SUBSTITUTED SULFONAMIDOBENZAMIDES, ANTIARRYTHMIC AGENTS AND COMPOSITIONS THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-04-20 | — | — | EP | disclosed |
| US-4629739-A | Substituted sulfonamidobenzamides and method of treating arrhythmias | SCHERING A.G. (DE) | 1986-12-16 | — | — | US | disclosed |
| EP-0158775-A1 | Substituted sulfonamidobenzamides, antiarrythmic agents and compositions thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-23 | — | — | EP | disclosed |
| US-4544654-A | Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof | SCHERING A.G. (DE) | 1985-10-01 | — | — | US | disclosed |