Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ADH5 | P11766 | 4/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648270 | 0.83 | TBXAS1 (0.40) | CYP3A4BAZ2BHTTTDP1ADH5 | |
| SCHEMBL10645714 | 0.80 | CYP3A4 (0.36) | CYP3A4BAZ2BHTTHTR2AHTR2C | |
| SCHEMBL11000190 | 0.79 | CYP3A4 (0.56) | CYP3A4BAZ2BHTTHTR2AHTR2C | |
| SCHEMBL10647455 | 0.78 | TBXAS1 (0.37) | CYP3A4BAZ2BHTTHTR2AHTR2C | |
| SCHEMBL10756776 | 0.77 | CYP3A4 (0.37) | CYP3A4BAZ2BHTTHTR2AHTR2C | |
| SCHEMBL10730531 | 0.77 | CYP3A4 (0.35) | CYP3A4BAZ2BHTTHTR2AHTR2C | |
| SCHEMBL10645502 | 0.77 | STING1 (0.39) | CYP3A4BAZ2BHTTADH5TBXAS1 | |
| SCHEMBL10651014 | 0.71 | TBXAS1 (0.48) | CYP3A4BAZ2BHTTHTR2AHTR2C | |
| SCHEMBL10365545 | 0.68 | CYP3A4 (0.47) | CYP3A4BAZ2BHTTHTR2AHTR2C | |
| SCHEMBL14282012 | 0.68 | CYP11B1 (0.42) | CYP3A4BAZ2BHTTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |