Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10650151 | 0.84 | CYP1A2 (0.41) | CYP1A2KMT2AMEN1POLBPKM | |
| SCHEMBL10646960 | 0.79 | HTT (0.39) | CYP1A2KMT2AMEN1POLBPKM | |
| SCHEMBL10645457 | 0.77 | CYP11B1 (0.56) | CYP1A2POLBPDE3APDE3BCYP11B1 | |
| SCHEMBL10648317 | 0.77 | CYP1A2 (0.39) | CYP1A2KMT2AMEN1POLBPKM | |
| SCHEMBL10651361 | 0.75 | KMT2A (0.38) | CYP1A2KMT2AMEN1POLBPKM | |
| SCHEMBL10648447 | 0.75 | CYP1A2 (0.41) | CYP1A2KMT2AMEN1POLBPKM | |
| SCHEMBL10646023 | 0.72 | SMN1; SMN2 (0.40) | CYP1A2KMT2ARAB9APDE3APDE3B | |
| SCHEMBL11115116 | 0.70 | PDE3B (0.44) | KMT2APDE3APDE3BCYP11B1CYP11B2 | |
| SCHEMBL10649242 | 0.69 | TSHR (0.40) | POLB | |
| SCHEMBL10651613 | 0.68 | PDE3B (0.43) | PDE3APDE3BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |